TY - JOUR
T1 - How to select optimal maintenance intravenous fluid therapy
AU - Shafiee, M. A.S.
AU - Bohn, D.
AU - Hoorn, E. J.
AU - Halperin, Mitchell L.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Hyponatraemia is the commonest electrolyte abnormality in hospitalized patients. If the plasma sodium concentration (PNa) declines to ∼ 120 mM in <48 h, brain cell swelling might result in herniation, with devastating consequences. The volume and/or the composition of fluids used for intravenous therapy often contribute to the development of acute hyponatraemia. Our hypothesis is that the traditional calculation of the daily loss of insensible water overestimates this parameter, leading to an excessive daily recommended requirement for water. We offer suggestions to minimize the risk of iatrogenic hyponatraemia.
AB - Hyponatraemia is the commonest electrolyte abnormality in hospitalized patients. If the plasma sodium concentration (PNa) declines to ∼ 120 mM in <48 h, brain cell swelling might result in herniation, with devastating consequences. The volume and/or the composition of fluids used for intravenous therapy often contribute to the development of acute hyponatraemia. Our hypothesis is that the traditional calculation of the daily loss of insensible water overestimates this parameter, leading to an excessive daily recommended requirement for water. We offer suggestions to minimize the risk of iatrogenic hyponatraemia.
UR - http://www.scopus.com/inward/record.url?scp=0042655185&partnerID=8YFLogxK
U2 - 10.1093/qjmed/hcg101
DO - 10.1093/qjmed/hcg101
M3 - Article
C2 - 12897346
AN - SCOPUS:0042655185
VL - 96
SP - 601
EP - 610
JO - QJM - Monthly Journal of the Association of Physicians
JF - QJM - Monthly Journal of the Association of Physicians
SN - 1460-2725
IS - 8
ER -