How to select optimal maintenance intravenous fluid therapy

M. A.S. Shafiee, D. Bohn, E. J. Hoorn, Mitchell L. Halperin*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

75 Citations (Scopus)


Hyponatraemia is the commonest electrolyte abnormality in hospitalized patients. If the plasma sodium concentration (PNa) declines to ∼ 120 mM in <48 h, brain cell swelling might result in herniation, with devastating consequences. The volume and/or the composition of fluids used for intravenous therapy often contribute to the development of acute hyponatraemia. Our hypothesis is that the traditional calculation of the daily loss of insensible water overestimates this parameter, leading to an excessive daily recommended requirement for water. We offer suggestions to minimize the risk of iatrogenic hyponatraemia.

Original languageEnglish
Pages (from-to)601-610
Number of pages10
JournalQJM - Monthly Journal of the Association of Physicians
Issue number8
Publication statusPublished - 1 Aug 2003


Dive into the research topics of 'How to select optimal maintenance intravenous fluid therapy'. Together they form a unique fingerprint.

Cite this