Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Monique Verstegen; Floris Roos; Kseniia Burka; H Gehart; M Jager; M (Maaike) de Wolf; Marcel Bijvelds; Hugo de Jonge; AI Ardisasmita; Nick van Huizen; Henk Roest; Jeroen de Jonge; M Koch; F Pampaloni; SA Fuchs; IF Schene; Theo Luider; HPJ van der Doef; FAJA Bodewes; R H J de Kleine; B Spee; Gert-Jan Kremers; H Clevers; J.N.M. IJzermans; E Cuppen; Luc van der Laan

doi:10.1038/s41598-020-79082-8

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Monique Verstegen
, Floris Roos
, Kseniia Burka
, H Gehart
, M Jager
, M (Maaike) de Wolf
, Marcel Bijvelds
, Hugo de Jonge
, AI Ardisasmita
, Nick van Huizen
, Henk Roest
, Jeroen de Jonge
, M Koch
, F Pampaloni
, SA Fuchs
, IF Schene
, Theo Luider
, HPJ van der Doef
, FAJA Bodewes
, R H J de Kleine

B Spee, Gert-Jan Kremers, H Clevers, J.N.M. IJzermans, E Cuppen, Luc van der Laan

Research output: Contribution to journal › Article › Academic › peer-review

73 Citations (Scopus)

48 Downloads (Pure)

Original language	English
Pages (from-to)	21900
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-79082-8
Publication status	Published - 2020

Research programs

EMC MM-03-24-01
EMC MM-03-44-06
EMC MM-04-20-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-020-79082-8

Repub_133022_O-A.pdfFinal published version, 2.38 MB

http://hdl.handle.net/1765/133022

Cite this

Verstegen, M., Roos, F., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M., de Jonge, H., Ardisasmita, AI., van Huizen, N., Roest, H., de Jonge, J., Koch, M., Pampaloni, F., Fuchs, SA., Schene, IF., Luider, T., van der Doef, HPJ., Bodewes, FAJA., ... van der Laan, L. (2020). Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease. Scientific Reports, 10(1), 21900. https://doi.org/10.1038/s41598-020-79082-8

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title = "Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease",

author = "Monique Verstegen and Floris Roos and Kseniia Burka and H Gehart and M Jager and \{de Wolf\}, \{M (Maaike)\} and Marcel Bijvelds and \{de Jonge\}, Hugo and AI Ardisasmita and \{van Huizen\}, Nick and Henk Roest and \{de Jonge\}, Jeroen and M Koch and F Pampaloni and SA Fuchs and IF Schene and Theo Luider and \{van der Doef\}, HPJ and FAJA Bodewes and \{de Kleine\}, \{R H J\} and B Spee and Gert-Jan Kremers and H Clevers and J.N.M. IJzermans and E Cuppen and \{van der Laan\}, Luc",

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Verstegen, M, Roos, F, Burka, K, Gehart, H, Jager, M, de Wolf, M, Bijvelds, M, de Jonge, H, Ardisasmita, AI, van Huizen, N, Roest, H , de Jonge, J, Koch, M, Pampaloni, F, Fuchs, SA, Schene, IF, Luider, T, van der Doef, HPJ, Bodewes, FAJA, de Kleine, RHJ, Spee, B, Kremers, G-J, Clevers, H, IJzermans, JNM, Cuppen, E & van der Laan, L 2020, 'Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease', Scientific Reports, vol. 10, no. 1, pp. 21900. https://doi.org/10.1038/s41598-020-79082-8

TY - JOUR

T1 - Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

AU - Verstegen, Monique

AU - Roos, Floris

AU - Burka, Kseniia

AU - Gehart, H

AU - Jager, M

AU - de Wolf, M (Maaike)

AU - Bijvelds, Marcel

AU - de Jonge, Hugo

AU - Ardisasmita, AI

AU - van Huizen, Nick

AU - Roest, Henk

AU - de Jonge, Jeroen

AU - Koch, M

AU - Pampaloni, F

AU - Fuchs, SA

AU - Schene, IF

AU - Luider, Theo

AU - van der Doef, HPJ

AU - Bodewes, FAJA

AU - de Kleine, R H J

AU - Spee, B

AU - Kremers, Gert-Jan

AU - Clevers, H

AU - IJzermans, J.N.M.

AU - Cuppen, E

AU - van der Laan, Luc

PY - 2020

Y1 - 2020

U2 - 10.1038/s41598-020-79082-8

DO - 10.1038/s41598-020-79082-8

M3 - Article

C2 - 33318612

SN - 2045-2322

VL - 10

SP - 21900

JO - Scientific Reports

JF - Scientific Reports

IS - 1

ER -