Human Influenza A Virus-Specific CD8(+) T-Cell Response Is Long-lived

Carolien Sandt; Marine Hillaire; Tiny Mieras; Ab Osterhaus; Ron Fouchier; Guus Rimmelzwaan

doi:10.1093/infdis/jiv018

Human Influenza A Virus-Specific CD8(+) T-Cell Response Is Long-lived

Carolien Sandt, Marine Hillaire, Tiny Mieras, Ab Osterhaus, Ron Fouchier, Guus Rimmelzwaan

Virology

Research output: Contribution to journal › Article › Academic › peer-review

50 Citations (Scopus)

Abstract

Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.

Original language	Undefined/Unknown
Pages (from-to)	81-85
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	212
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiv018
Publication status	Published - 2015

Research programs

EMC MM-04-27-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/jiv018

Cite this

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abstract = "Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.",

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AU - Fouchier, Ron

AU - Rimmelzwaan, Guus

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AB - Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.

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