Human lymph node development: An inflammatory interaction

Tom Cupedo*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)

Abstract

In the developing human fetus, lymph nodes and Peyer's patches are formed during the first and second trimester of pregnancy. The cells responsible for this process, lymphoid tissue inducer (LTi) cells, share a number of characteristics with Natural Killer (NK) cells and produce cytokines related to inflammation. Here I will discuss recent advances in our understanding of human lymph node development, in particular the characterization of LTi cells and the relationship of these innate lymphocytes to conventional NK cells.

Original languageEnglish
Pages (from-to)4-6
Number of pages3
JournalImmunology Letters
Volume138
Issue number1
DOIs
Publication statusPublished - Jul 2011

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