Human norovirus transmission and evolution in a changing world

Miranda de Graaf, J (Janko) van Beek, Marion Koopmans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

356 Citations (Scopus)

Abstract

Norovirus infections are a major cause of gastroenteritis, and outbreaks occur frequently. Several factors are currently increasing the challenge posed by norovirus infections to global health, notably the increasing number of infections in immunocompromised individuals, who are more susceptible to disease, and the globalization of the food industry, which enables large norovirus outbreaks to occur on an international scale. Furthermore, the rapid rate of the genetic and antigenic evolution of circulating noroviruses complicates the development of vaccines and therapies that are required to counter these challenges. In this Review, we describe recent advances in the study of the transmission, pathogenesis and evolution of human noroviruses, and consider the ongoing risk of norovirus outbreaks, together with the future prospects for therapeutics, in a rapidly changing world.

Original languageEnglish
Pages (from-to)421-433
Number of pages13
JournalNature Reviews Microbiology
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2016

Research programs

  • EMC MM-04-27-01

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