TY - JOUR
T1 - Human papillomavirus infection in a population-based sample of women in Algiers, Algeria
AU - Hammouda, Doudja
AU - Clifford, Gary M.
AU - Pallardy, Sophie
AU - Ayyach, Ghassan
AU - Chékiri, Asma
AU - Boudrich, Arab
AU - Snijders, Peter J.F.
AU - Van Kemenade, Folkert J.
AU - Meijer, Chris J.L.M.
AU - Bouhadef, Anissa
AU - Zitouni, Zahia
AU - Habib, Djamila
AU - Ikezaren, Nadia
AU - Franceschi, Silvia
PY - 2011/5/1
Y1 - 2011/5/1
N2 - No data exist on the population prevalence of, nor risk factors for, human papillomavirus (HPV) infection in the predominantly Muslim countries of Northern Africa. Cervical specimens were obtained from 759 married women aged 15-65 years from the general population of Algiers, Algeria. Liquid-based cytology and HPV DNA detection, using a GP5+/6+-based polymerase chain reaction assay that detects 44 HPV types, were performed according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV prevalence in the general population was 6.3% (4.0% of high-risk types), with no significant variation by age. The prevalence of cervical abnormalities was 3.6%. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's extramarital sexual relationships. HPV16/18 accounted for only 15% of HPV-positive women in the general population, compared with 77% of invasive cervical cancer diagnosed in the same city. In conclusion, we report that HPV infection among married women in Algeria is much lower than in sub-Saharan Africa and also lower than in the majority of high-resource countries.
AB - No data exist on the population prevalence of, nor risk factors for, human papillomavirus (HPV) infection in the predominantly Muslim countries of Northern Africa. Cervical specimens were obtained from 759 married women aged 15-65 years from the general population of Algiers, Algeria. Liquid-based cytology and HPV DNA detection, using a GP5+/6+-based polymerase chain reaction assay that detects 44 HPV types, were performed according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV prevalence in the general population was 6.3% (4.0% of high-risk types), with no significant variation by age. The prevalence of cervical abnormalities was 3.6%. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's extramarital sexual relationships. HPV16/18 accounted for only 15% of HPV-positive women in the general population, compared with 77% of invasive cervical cancer diagnosed in the same city. In conclusion, we report that HPV infection among married women in Algeria is much lower than in sub-Saharan Africa and also lower than in the majority of high-resource countries.
UR - http://www.scopus.com/inward/record.url?scp=79952481941&partnerID=8YFLogxK
U2 - 10.1002/ijc.25539
DO - 10.1002/ijc.25539
M3 - Article
C2 - 20607828
AN - SCOPUS:79952481941
SN - 0020-7136
VL - 128
SP - 2224
EP - 2229
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 9
ER -
