Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition

E Reiling; EN Speksnijder; ACM Pronk; Sjoerd van den Berg; SJW Neggers; I Rietbroek; H van Steeg; Martijn Dollé

doi:10.1038/srep04091

Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition

E Reiling, EN Speksnijder, ACM Pronk, Sjoerd van den Berg, SJW Neggers, I Rietbroek, H van Steeg, Martijn Dollé

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Abstract

Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.

Original language	Undefined/Unknown
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep04091
Publication status	Published - 13 Feb 2014
Externally published	Yes

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10.1038/srep04091Licence: CC BY-NC-ND

Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body compositionFinal published version, 446 KBLicence: CC BY-NC-ND

Cite this

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title = "Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition",

abstract = "Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.",

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T1 - Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition

AU - Reiling, E

AU - Speksnijder, EN

AU - Pronk, ACM

AU - van den Berg, Sjoerd

AU - Neggers, SJW

AU - Rietbroek, I

AU - van Steeg, H

AU - Dollé, Martijn

PY - 2014/2/13

Y1 - 2014/2/13

N2 - Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.

AB - Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.

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DO - 10.1038/srep04091

M3 - Article

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SN - 2045-2322

VL - 4

JO - Scientific Reports

JF - Scientific Reports

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