Hypercalcemia during pregnancy: management and outcomes for mother and child

Natasha M. Appelman-Dijkstra*, Diana Alexandra Ertl, M. Carola Zillikens, Lars Rjenmark, Elizabeth M. Winter

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
3 Downloads (Pure)


Diagnosing and treating hypercalcemia during pregnancy can be challenging due to both the physiological changes in calcium homeostasis and the underlying cause for the hypercalcemia. During pregnancy and lactation there is increased mobilization of calcium in the mother to meet the fetus’ calcium requirements. Here we discuss the diagnostic challenges, management, and patient perspective of hypercalcemia during pregnancy in two particular cases and in other rare conditions causing hypercalcemia.

Original languageEnglish
Pages (from-to)604-610
Number of pages7
Issue number3
Publication statusPublished - Mar 2021

Bibliographical note

Funding Information:
We would like to acknowledge the European Reference Network for Rare Endocrine diseases, specifically main thematic group two calcium and phosphate disorders. We would like to thank both C.W.M. Janssen and S. Mourits for their agreement on publication of their medical history and contribution to the content of the manuscript. Conceptualization, writing original draft preparation, reviewing and editing: N.M.A-D. Reviewing and editing, critically revising the manuscript: D-A.E, M.C.Z, L.R, and E.M.W.

Publisher Copyright:
© 2021, The Author(s).


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