Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

Robert Rozenberg; RT Mankowski; LJC van Loon; Janneke Langendonk; E.J.G. Sijbrands; Ton van den Meiracker; Henk Stam; SFE Praet

doi:10.1186/s40001-015-0194-5

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

Robert Rozenberg, RT Mankowski, LJC van Loon, Janneke Langendonk, E.J.G. Sijbrands, Ton van den Meiracker, Henk Stam, SFE Praet

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % W-max) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO(2) levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

Original language	Undefined/Unknown
Journal	European Journal of Medical Research
Volume	21
DOIs	https://doi.org/10.1186/s40001-015-0194-5
Publication status	Published - 2016

Research programs

EMC COEUR-09
EMC COEUR-09-39-01
EMC COEUR-09-39-02
EMC MUSC-01-46-01

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10.1186/s40001-015-0194-5

REPUB_87130_OA.pdfFinal published version, 977 KB

http://hdl.handle.net/1765/87130

Cite this

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title = "Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study",

abstract = "Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % W-max) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO(2) levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.",

author = "Robert Rozenberg and RT Mankowski and {van Loon}, LJC and Janneke Langendonk and E.J.G. Sijbrands and {van den Meiracker}, Ton and Henk Stam and SFE Praet",

year = "2016",

doi = "10.1186/s40001-015-0194-5",

language = "Undefined/Unknown",

volume = "21",

journal = "European Journal of Medical Research",

issn = "0949-2321",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

AU - Rozenberg, Robert

AU - Mankowski, RT

AU - van Loon, LJC

AU - Langendonk, Janneke

AU - Sijbrands, E.J.G.

AU - van den Meiracker, Ton

AU - Stam, Henk

AU - Praet, SFE

PY - 2016

Y1 - 2016

N2 - Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % W-max) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO(2) levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

AB - Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). Methods: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % W-max) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO(2) levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

U2 - 10.1186/s40001-015-0194-5

DO - 10.1186/s40001-015-0194-5

M3 - Article

SN - 0949-2321

VL - 21

JO - European Journal of Medical Research

JF - European Journal of Medical Research

ER -