Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

Berina Eppink, PM Krawczyk, J Stap, Roland Kanaar

Research output: Contribution to journalArticleAcademicpeer-review

88 Citations (Scopus)

Abstract

Local hyperthermia is an effective treatment modality to augment radio-and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.
Original languageUndefined/Unknown
Pages (from-to)509-517
Number of pages9
JournalInternational Journal of Hyperthermia
Volume28
Issue number6
DOIs
Publication statusPublished - 2012

Research programs

  • EMC MGC-01-12-03
  • EMC MM-03-32-04

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