Abstract
Local hyperthermia is an effective treatment modality to augment radio-and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.
Original language | Undefined/Unknown |
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Pages (from-to) | 509-517 |
Number of pages | 9 |
Journal | International Journal of Hyperthermia |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2012 |
Research programs
- EMC MGC-01-12-03
- EMC MM-03-32-04