Hypothalamus volume in twin pairs discordant for schizophrenia

P. Cédric M.P. Koolschijn*, Neeltje E.M. van Haren, Hilleke E. Hulshoff Pol, René S. Kahn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Abstract

Monozygotic and same-sex dizygotic twin pairs discordant for schizophrenia were compared with matched control twin pairs in order to disentangle genetic and environmental contributions to variation in hypothalamus volume. A decrease in hypothalamus volume was found in patients or discordant twin pairs compared to healthy controls which could be attributed to the decrease in total brain volume. Higher within-twin pair similarities in monozygotic compared to dizygotic twin pairs, suggests that hypothalamus volume might be partly genetically controlled.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalEuropean Neuropsychopharmacology
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2008
Externally publishedYes

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