IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Y Momozawa; J Dmitrieva; E Theatre; V Deffontaine; S Rahmouni; B Charloteaux; F Crins; E Docampo; M Elansary; AS Gori; C Lecut; R Mariman; M Mni; C Oury; I Altukhov; D Alexeev; Y Aulchenko; L Amininejad; G Bouma; F Hoentjen; M Lowenberg; B Oldenburg; MJ Pierik; AE de Jong; C.J. van der Woude; MC Visschedijk; M Lathrop; JP Hugot; RK Weersma; M Vos; D Franchimont; S Vermeire; M Kubo; E Louis; M Georges; C Abraham; JP Achkar; T Ahmad; AN Ananthakrishnan; V Andersen; CA Anderson; JM Andrews; V Annese; G Aumais; L Baidoo; RN Baldassano; PA Bampton; M Barclay; JC Barrett; TM Bayless; J Bethge; A Bitton; G Boucher; S Brand; B Brandt; SR Brant; C Buning; A Chew; JH Cho; I Cleynen; A Cohain; A Croft; MJ Daly; M D'Amato; S Danese; D Jong; G Denapiene; LA Denson; KL Devaney; O Dewit; R D'Inca; M Dubinsky; RH Duerr; C Edwards; D Ellinghaus; J Essers; LR Ferguson; EA Festen; P Fleshner; T Florin; A Franke; K Fransen; R Gearry; C Gieger; J Glas; P Goyette; T Green; AM Griffiths; SL Guthery; H Hakonarson; J Halfvarson; K Hanigan; T Haritunians; A de Hart; C Hawkey; NK Hayward; M Hedl; P Henderson; XH Hu; HL Huang; KY Hui; M Imielinski; A Ippoliti; L Jonaitis; L Jostins; TH Karlsen; NA Kennedy; MA Khan; G Kiudelis; K Krishnaprasad; S Kugathasan; L Kupcinskas; A Latiano; D Laukens; IC Lawrance; JC Lee; CW Lees; M Leja; J van Limbergen; P Lionetti; JZ Liu; G Mahy; J Mansfield; D Massey; CG Mathew; DPB McGovern; R Milgrom; M Mitrovic; GW Montgomery; C Mowat; W Newman; A Ng; SC Ng; SME Ng; S Nikolaus; K Ning; M Nothen; I Oikonomou; O Palmieri; M Parkes; A Phillips; CY Ponsioen; U Potocnik; NJ Prescott; DD Proctor; G Radford-Smith; JF Rahier; S Raychaudhuri; M Regueiro; F Rieder; JD Rioux; S Ripke; R Roberts; RK Russell; JD Sanderson; M Sans; J Satsangi; EE Schadt; S Schreiber; D Schulte; LP Schumm; R Scott; M Seielstad; Y Sharma; MS Silverberg; LA Simms; J Skieceviciene; SL Spain; AH Steinhart; JM Stempak; L Stronati; J Sventoraityte; SR Targan; KM Taylor; A Velde; L Torkvist; M Tremelling; S van Sommeren; E Vasiliauskas; HW Verspaget; T Walters; K Wang; MH Wang; Z Wei; D Whiteman; C Wijmenga; DC Wilson; J Winkelmann; RJ Xavier; B Zhang; CK Zhang; H Zhang; W Zhang; HY Zhao; ZZ Zhao

doi:10.1038/s41467-018-04365-8

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Y Momozawa, J Dmitrieva, E Theatre, V Deffontaine, S Rahmouni, B Charloteaux, F Crins, E Docampo, M Elansary, AS Gori, C Lecut, R Mariman, M Mni, C Oury, I Altukhov, D Alexeev, Y Aulchenko, L Amininejad, G Bouma, F HoentjenM Lowenberg, B Oldenburg, MJ Pierik, AE de Jong, C.J. van der Woude, MC Visschedijk, M Lathrop, JP Hugot, RK Weersma, M Vos, D Franchimont, S Vermeire, M Kubo, E Louis, M Georges, C Abraham, JP Achkar, T Ahmad, AN Ananthakrishnan, V Andersen, CA Anderson, JM Andrews, V Annese, G Aumais, L Baidoo, RN Baldassano, PA Bampton, M Barclay, JC Barrett, TM Bayless, J Bethge, A Bitton, G Boucher, S Brand, B Brandt, SR Brant, C Buning, A Chew, JH Cho, I Cleynen, A Cohain, A Croft, MJ Daly, M D'Amato, S Danese, D Jong, G Denapiene, LA Denson, KL Devaney, O Dewit, R D'Inca, M Dubinsky, RH Duerr, C Edwards, D Ellinghaus, J Essers, LR Ferguson, EA Festen, P Fleshner, T Florin, A Franke, K Fransen, R Gearry, C Gieger, J Glas, P Goyette, T Green, AM Griffiths, SL Guthery, H Hakonarson, J Halfvarson, K Hanigan, T Haritunians, A de Hart, C Hawkey, NK Hayward, M Hedl, P Henderson, XH Hu, HL Huang, KY Hui, M Imielinski, A Ippoliti, L Jonaitis, L Jostins, TH Karlsen, NA Kennedy, MA Khan, G Kiudelis, K Krishnaprasad, S Kugathasan, L Kupcinskas, A Latiano, D Laukens, IC Lawrance, JC Lee, CW Lees, M Leja, J van Limbergen, P Lionetti, JZ Liu, G Mahy, J Mansfield, D Massey, CG Mathew, DPB McGovern, R Milgrom, M Mitrovic, GW Montgomery, C Mowat, W Newman, A Ng, SC Ng, SME Ng, S Nikolaus, K Ning, M Nothen, I Oikonomou, O Palmieri, M Parkes, A Phillips, CY Ponsioen, U Potocnik, NJ Prescott, DD Proctor, G Radford-Smith, JF Rahier, S Raychaudhuri, M Regueiro, F Rieder, JD Rioux, S Ripke, R Roberts, RK Russell, JD Sanderson, M Sans, J Satsangi, EE Schadt, S Schreiber, D Schulte, LP Schumm, R Scott, M Seielstad, Y Sharma, MS Silverberg, LA Simms, J Skieceviciene, SL Spain, AH Steinhart, JM Stempak, L Stronati, J Sventoraityte, SR Targan, KM Taylor, A Velde, L Torkvist, M Tremelling, S van Sommeren, E Vasiliauskas, HW Verspaget, T Walters, K Wang, MH Wang, Z Wei, D Whiteman, C Wijmenga, DC Wilson, J Winkelmann, RJ Xavier, B Zhang, CK Zhang, H Zhang, W Zhang, HY Zhao, ZZ Zhao

Gastroenterology & Hepatology

Research output: Contribution to journal › Article › Academic › peer-review

135 Citations (Scopus)

28 Downloads (Pure)

Original language	Undefined/Unknown
Article number	2427
Journal	Nature Communications
Volume	9
DOIs	https://doi.org/10.1038/s41467-018-04365-8
Publication status	Published - 2018

Research programs

EMC MM-04-20-01

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10.1038/s41467-018-04365-8

REPUB_109022_OA.pdfFinal published version, 1.75 MB

http://hdl.handle.net/1765/109022

Cite this

Momozawa, Y., Dmitrieva, J., Theatre, E., Deffontaine, V., Rahmouni, S., Charloteaux, B., Crins, F., Docampo, E., Elansary, M., Gori, AS., Lecut, C., Mariman, R., Mni, M., Oury, C., Altukhov, I., Alexeev, D., Aulchenko, Y., Amininejad, L., Bouma, G., ... Zhao, ZZ. (2018). IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications, 9, Article 2427. https://doi.org/10.1038/s41467-018-04365-8

@article{7c1e18e7431840e1ad77fcc5716ce0cd,

title = "IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes",

author = "Y Momozawa and J Dmitrieva and E Theatre and V Deffontaine and S Rahmouni and B Charloteaux and F Crins and E Docampo and M Elansary and AS Gori and C Lecut and R Mariman and M Mni and C Oury and I Altukhov and D Alexeev and Y Aulchenko and L Amininejad and G Bouma and F Hoentjen and M Lowenberg and B Oldenburg and MJ Pierik and {de Jong}, AE and {van der Woude}, C.J. and MC Visschedijk and M Lathrop and JP Hugot and RK Weersma and M Vos and D Franchimont and S Vermeire and M Kubo and E Louis and M Georges and C Abraham and JP Achkar and T Ahmad and AN Ananthakrishnan and V Andersen and CA Anderson and JM Andrews and V Annese and G Aumais and L Baidoo and RN Baldassano and PA Bampton and M Barclay and JC Barrett and TM Bayless and J Bethge and A Bitton and G Boucher and S Brand and B Brandt and SR Brant and C Buning and A Chew and JH Cho and I Cleynen and A Cohain and A Croft and MJ Daly and M D'Amato and S Danese and D Jong and G Denapiene and LA Denson and KL Devaney and O Dewit and R D'Inca and M Dubinsky and RH Duerr and C Edwards and D Ellinghaus and J Essers and LR Ferguson and EA Festen and P Fleshner and T Florin and A Franke and K Fransen and R Gearry and C Gieger and J Glas and P Goyette and T Green and AM Griffiths and SL Guthery and H Hakonarson and J Halfvarson and K Hanigan and T Haritunians and {de Hart}, A and C Hawkey and NK Hayward and M Hedl and P Henderson and XH Hu and HL Huang and KY Hui and M Imielinski and A Ippoliti and L Jonaitis and L Jostins and TH Karlsen and NA Kennedy and MA Khan and G Kiudelis and K Krishnaprasad and S Kugathasan and L Kupcinskas and A Latiano and D Laukens and IC Lawrance and JC Lee and CW Lees and M Leja and {van Limbergen}, J and P Lionetti and JZ Liu and G Mahy and J Mansfield and D Massey and CG Mathew and DPB McGovern and R Milgrom and M Mitrovic and GW Montgomery and C Mowat and W Newman and A Ng and SC Ng and SME Ng and S Nikolaus and K Ning and M Nothen and I Oikonomou and O Palmieri and M Parkes and A Phillips and CY Ponsioen and U Potocnik and NJ Prescott and DD Proctor and G Radford-Smith and JF Rahier and S Raychaudhuri and M Regueiro and F Rieder and JD Rioux and S Ripke and R Roberts and RK Russell and JD Sanderson and M Sans and J Satsangi and EE Schadt and S Schreiber and D Schulte and LP Schumm and R Scott and M Seielstad and Y Sharma and MS Silverberg and LA Simms and J Skieceviciene and SL Spain and AH Steinhart and JM Stempak and L Stronati and J Sventoraityte and SR Targan and KM Taylor and A Velde and L Torkvist and M Tremelling and {van Sommeren}, S and E Vasiliauskas and HW Verspaget and T Walters and K Wang and MH Wang and Z Wei and D Whiteman and C Wijmenga and DC Wilson and J Winkelmann and RJ Xavier and B Zhang and CK Zhang and H Zhang and W Zhang and HY Zhao and ZZ Zhao",

year = "2018",

doi = "10.1038/s41467-018-04365-8",

language = "Undefined/Unknown",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Momozawa, Y, Dmitrieva, J, Theatre, E, Deffontaine, V, Rahmouni, S, Charloteaux, B, Crins, F, Docampo, E, Elansary, M, Gori, AS, Lecut, C, Mariman, R, Mni, M, Oury, C, Altukhov, I, Alexeev, D, Aulchenko, Y, Amininejad, L, Bouma, G, Hoentjen, F, Lowenberg, M, Oldenburg, B, Pierik, MJ, de Jong, AE, van der Woude, CJ, Visschedijk, MC, Lathrop, M, Hugot, JP, Weersma, RK, Vos, M, Franchimont, D, Vermeire, S, Kubo, M, Louis, E, Georges, M, Abraham, C, Achkar, JP, Ahmad, T, Ananthakrishnan, AN, Andersen, V, Anderson, CA, Andrews, JM, Annese, V, Aumais, G, Baidoo, L, Baldassano, RN, Bampton, PA, Barclay, M, Barrett, JC, Bayless, TM, Bethge, J, Bitton, A, Boucher, G, Brand, S, Brandt, B, Brant, SR, Buning, C, Chew, A, Cho, JH, Cleynen, I, Cohain, A, Croft, A, Daly, MJ, D'Amato, M, Danese, S, Jong, D, Denapiene, G, Denson, LA, Devaney, KL, Dewit, O, D'Inca, R, Dubinsky, M, Duerr, RH, Edwards, C, Ellinghaus, D, Essers, J, Ferguson, LR, Festen, EA, Fleshner, P, Florin, T, Franke, A, Fransen, K, Gearry, R, Gieger, C, Glas, J, Goyette, P, Green, T, Griffiths, AM, Guthery, SL, Hakonarson, H, Halfvarson, J, Hanigan, K, Haritunians, T, de Hart, A, Hawkey, C, Hayward, NK, Hedl, M, Henderson, P, Hu, XH, Huang, HL, Hui, KY, Imielinski, M, Ippoliti, A, Jonaitis, L, Jostins, L, Karlsen, TH, Kennedy, NA, Khan, MA, Kiudelis, G, Krishnaprasad, K, Kugathasan, S, Kupcinskas, L, Latiano, A, Laukens, D, Lawrance, IC, Lee, JC, Lees, CW, Leja, M, van Limbergen, J, Lionetti, P, Liu, JZ, Mahy, G, Mansfield, J, Massey, D, Mathew, CG, McGovern, DPB, Milgrom, R, Mitrovic, M, Montgomery, GW, Mowat, C, Newman, W, Ng, A, Ng, SC, Ng, SME, Nikolaus, S, Ning, K, Nothen, M, Oikonomou, I, Palmieri, O, Parkes, M, Phillips, A, Ponsioen, CY, Potocnik, U, Prescott, NJ, Proctor, DD, Radford-Smith, G, Rahier, JF, Raychaudhuri, S, Regueiro, M, Rieder, F, Rioux, JD, Ripke, S, Roberts, R, Russell, RK, Sanderson, JD, Sans, M, Satsangi, J, Schadt, EE, Schreiber, S, Schulte, D, Schumm, LP, Scott, R, Seielstad, M, Sharma, Y, Silverberg, MS, Simms, LA, Skieceviciene, J, Spain, SL, Steinhart, AH, Stempak, JM, Stronati, L, Sventoraityte, J, Targan, SR, Taylor, KM, Velde, A, Torkvist, L, Tremelling, M, van Sommeren, S, Vasiliauskas, E, Verspaget, HW, Walters, T, Wang, K, Wang, MH, Wei, Z, Whiteman, D, Wijmenga, C, Wilson, DC, Winkelmann, J, Xavier, RJ, Zhang, B, Zhang, CK, Zhang, H, Zhang, W, Zhao, HY & Zhao, ZZ 2018, 'IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes', Nature Communications, vol. 9, 2427. https://doi.org/10.1038/s41467-018-04365-8

TY - JOUR

T1 - IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

AU - Momozawa, Y

AU - Dmitrieva, J

AU - Theatre, E

AU - Deffontaine, V

AU - Rahmouni, S

AU - Charloteaux, B

AU - Crins, F

AU - Docampo, E

AU - Elansary, M

AU - Gori, AS

AU - Lecut, C

AU - Mariman, R

AU - Mni, M

AU - Oury, C

AU - Altukhov, I

AU - Alexeev, D

AU - Aulchenko, Y

AU - Amininejad, L

AU - Bouma, G

AU - Hoentjen, F

AU - Lowenberg, M

AU - Oldenburg, B

AU - Pierik, MJ

AU - de Jong, AE

AU - van der Woude, C.J.

AU - Visschedijk, MC

AU - Lathrop, M

AU - Hugot, JP

AU - Weersma, RK

AU - Vos, M

AU - Franchimont, D

AU - Vermeire, S

AU - Kubo, M

AU - Louis, E

AU - Georges, M

AU - Abraham, C

AU - Achkar, JP

AU - Ahmad, T

AU - Ananthakrishnan, AN

AU - Andersen, V

AU - Anderson, CA

AU - Andrews, JM

AU - Annese, V

AU - Aumais, G

AU - Baidoo, L

AU - Baldassano, RN

AU - Bampton, PA

AU - Barclay, M

AU - Barrett, JC

AU - Bayless, TM

AU - Bethge, J

AU - Bitton, A

AU - Boucher, G

AU - Brand, S

AU - Brandt, B

AU - Brant, SR

AU - Buning, C

AU - Chew, A

AU - Cho, JH

AU - Cleynen, I

AU - Cohain, A

AU - Croft, A

AU - Daly, MJ

AU - D'Amato, M

AU - Danese, S

AU - Jong, D

AU - Denapiene, G

AU - Denson, LA

AU - Devaney, KL

AU - Dewit, O

AU - D'Inca, R

AU - Dubinsky, M

AU - Duerr, RH

AU - Edwards, C

AU - Ellinghaus, D

AU - Essers, J

AU - Ferguson, LR

AU - Festen, EA

AU - Fleshner, P

AU - Florin, T

AU - Franke, A

AU - Fransen, K

AU - Gearry, R

AU - Gieger, C

AU - Glas, J

AU - Goyette, P

AU - Green, T

AU - Griffiths, AM

AU - Guthery, SL

AU - Hakonarson, H

AU - Halfvarson, J

AU - Hanigan, K

AU - Haritunians, T

AU - de Hart, A

AU - Hawkey, C

AU - Hayward, NK

AU - Hedl, M

AU - Henderson, P

AU - Hu, XH

AU - Huang, HL

AU - Hui, KY

AU - Imielinski, M

AU - Ippoliti, A

AU - Jonaitis, L

AU - Jostins, L

AU - Karlsen, TH

AU - Kennedy, NA

AU - Khan, MA

AU - Kiudelis, G

AU - Krishnaprasad, K

AU - Kugathasan, S

AU - Kupcinskas, L

AU - Latiano, A

AU - Laukens, D

AU - Lawrance, IC

AU - Lee, JC

AU - Lees, CW

AU - Leja, M

AU - van Limbergen, J

AU - Lionetti, P

AU - Liu, JZ

AU - Mahy, G

AU - Mansfield, J

AU - Massey, D

AU - Mathew, CG

AU - McGovern, DPB

AU - Milgrom, R

AU - Mitrovic, M

AU - Montgomery, GW

AU - Mowat, C

AU - Newman, W

AU - Ng, A

AU - Ng, SC

AU - Ng, SME

AU - Nikolaus, S

AU - Ning, K

AU - Nothen, M

AU - Oikonomou, I

AU - Palmieri, O

AU - Parkes, M

AU - Phillips, A

AU - Ponsioen, CY

AU - Potocnik, U

AU - Prescott, NJ

AU - Proctor, DD

AU - Radford-Smith, G

AU - Rahier, JF

AU - Raychaudhuri, S

AU - Regueiro, M

AU - Rieder, F

AU - Rioux, JD

AU - Ripke, S

AU - Roberts, R

AU - Russell, RK

AU - Sanderson, JD

AU - Sans, M

AU - Satsangi, J

AU - Schadt, EE

AU - Schreiber, S

AU - Schulte, D

AU - Schumm, LP

AU - Scott, R

AU - Seielstad, M

AU - Sharma, Y

AU - Silverberg, MS

AU - Simms, LA

AU - Skieceviciene, J

AU - Spain, SL

AU - Steinhart, AH

AU - Stempak, JM

AU - Stronati, L

AU - Sventoraityte, J

AU - Targan, SR

AU - Taylor, KM

AU - Velde, A

AU - Torkvist, L

AU - Tremelling, M

AU - van Sommeren, S

AU - Vasiliauskas, E

AU - Verspaget, HW

AU - Walters, T

AU - Wang, K

AU - Wang, MH

AU - Wei, Z

AU - Whiteman, D

AU - Wijmenga, C

AU - Wilson, DC

AU - Winkelmann, J

AU - Xavier, RJ

AU - Zhang, B

AU - Zhang, CK

AU - Zhang, H

AU - Zhang, W

AU - Zhao, HY

AU - Zhao, ZZ

PY - 2018

Y1 - 2018

U2 - 10.1038/s41467-018-04365-8

DO - 10.1038/s41467-018-04365-8

M3 - Article

C2 - 29930244

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 2427

ER -