TY - JOUR
T1 - Ideal outcome after pancreatic resection for neuroendocrine tumors
T2 - a nationwide study
AU - Chen, Jeffrey W.
AU - Dutch Pancreatic Cancer Group
AU - Augustinus, Simone A.
AU - Bonsing, Bert A.
AU - Bouwense, Stefan A.W.
AU - De Hingh, Ignace H.J.T.
AU - Van Eijck, Casper H.
AU - Groot Koerkamp, Bas
AU - Hendriks, Tessa E.
AU - Engelsman, Anton F.
AU - Besselink, Marc G.
AU - Nieveen van Dijkum, Els J.M.
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/1/7
Y1 - 2025/1/7
N2 - Background: Pancreatic resections for pancreatic neuroendocrine tumors (pNET) may experience a higher complication rate than for pancreatic ductal adenocarcinoma (PDAC). This study aimed to determine the rate of the novel composite “Ideal Outcome” measure after resection for pNET, using PDAC as reference. Methods: This observational cohort study included all consecutive patients after pancreatic resection for pNET and PDAC using the nationwide Dutch Pancreatic Cancer Audit (2014–2021). The primary outcome was Ideal Outcome; absence of postoperative mortality, postoperative pancreatic fistulas (POPF) grade B/C, other major complications, prolonged length of stay, reoperations and readmissions. Results: In total, 524 pNET and 2851 PDAC resections were included. The rate of Ideal Outcome was lower after resection for pNET (47.7% versus 55.7%; P<0.001) as compared to PDAC. This difference was driven by a lower rate of Ideal Outcome after pancreatoduodenectomy for pNET (37.7% versus 56.3%; P<0.001), with no difference after left pancreatectomy (54.5% versus 52.5%; P=0.598). Among the individual components of Ideal Outcome after pancreatoduodenectomy, the largest difference was a four times higher rate of POPF (32.1% versus 7.9%; P<0.001) after resection of pNET. Conclusion: Patients undergoing pancreatoduodenectomy for pNET have a reduced Ideal Outcome rate compared to patients with PDAC, related to a fourfold increased risk of POPF. This highlights the value of pNET-specific patient counseling and the need for effective POPF mitigation strategies.
AB - Background: Pancreatic resections for pancreatic neuroendocrine tumors (pNET) may experience a higher complication rate than for pancreatic ductal adenocarcinoma (PDAC). This study aimed to determine the rate of the novel composite “Ideal Outcome” measure after resection for pNET, using PDAC as reference. Methods: This observational cohort study included all consecutive patients after pancreatic resection for pNET and PDAC using the nationwide Dutch Pancreatic Cancer Audit (2014–2021). The primary outcome was Ideal Outcome; absence of postoperative mortality, postoperative pancreatic fistulas (POPF) grade B/C, other major complications, prolonged length of stay, reoperations and readmissions. Results: In total, 524 pNET and 2851 PDAC resections were included. The rate of Ideal Outcome was lower after resection for pNET (47.7% versus 55.7%; P<0.001) as compared to PDAC. This difference was driven by a lower rate of Ideal Outcome after pancreatoduodenectomy for pNET (37.7% versus 56.3%; P<0.001), with no difference after left pancreatectomy (54.5% versus 52.5%; P=0.598). Among the individual components of Ideal Outcome after pancreatoduodenectomy, the largest difference was a four times higher rate of POPF (32.1% versus 7.9%; P<0.001) after resection of pNET. Conclusion: Patients undergoing pancreatoduodenectomy for pNET have a reduced Ideal Outcome rate compared to patients with PDAC, related to a fourfold increased risk of POPF. This highlights the value of pNET-specific patient counseling and the need for effective POPF mitigation strategies.
UR - https://www.scopus.com/pages/publications/85215560405
U2 - 10.1016/j.hpb.2024.12.024
DO - 10.1016/j.hpb.2024.12.024
M3 - Article
C2 - 39828467
AN - SCOPUS:85215560405
SN - 1365-182X
VL - 27
SP - 562
EP - 571
JO - HPB
JF - HPB
IS - 4
ER -
