Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

K Gertow; B Sennblad; RJ Strawbridge; J Ohrvik; D Zabaneh; S Shah; F Veglia; C Fava; Maryam Kavousi; S McLachlan; M Kivimaki; JL Bolton; L Folkersen; B Gigante; K Leander; M Vikstrom; M Larsson; A Silveira; J Deanfield; BF Voight; P Fontanillas; M Sabater-Lleal; GI Colombo; M Kumari; C Langenberg; NJ Wareham; André Uitterlinden; A Gabrielsen; U Hedin; A Franco-Cereceda; K Nyyssonen; R Rauramaa; TP Tuomainen; K Savonen; AJ Smit; P Giral; E Mannarino; CM Robertson; PJ Talmud; B Hedblad; Bert Hofman; J Erdmann; MP Reilly; CJ O'Donnell; M Farrall; R Clarke; MG Franzosi; U Seedorf; AC Syvanen; GK Hansson; P Eriksson; NJ Samani; H Watkins; JF Price; AD Hingorani; O Melander; JCM Witteman; D Baldassarre; E Tremoli; U de Faire; SE Humphries; A Hamsten

doi:10.1161/CIRCGENETICS.112.963660

Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

K Gertow, B Sennblad, RJ Strawbridge, J Ohrvik, D Zabaneh, S Shah, F Veglia, C Fava, Maryam Kavousi, S McLachlan, M Kivimaki, JL Bolton, L Folkersen, B Gigante, K Leander, M Vikstrom, M Larsson, A Silveira, J Deanfield, BF VoightP Fontanillas, M Sabater-Lleal, GI Colombo, M Kumari, C Langenberg, NJ Wareham, André Uitterlinden, A Gabrielsen, U Hedin, A Franco-Cereceda, K Nyyssonen, R Rauramaa, TP Tuomainen, K Savonen, AJ Smit, P Giral, E Mannarino, CM Robertson, PJ Talmud, B Hedblad, Bert Hofman, J Erdmann, MP Reilly, CJ O'Donnell, M Farrall, R Clarke, MG Franzosi, U Seedorf, AC Syvanen, GK Hansson, P Eriksson, NJ Samani, H Watkins, JF Price, AD Hingorani, O Melander, JCM Witteman, D Baldassarre, E Tremoli, U de Faire, SE Humphries, A Hamsten

Research output: Contribution to journal › Article › Academic

33 Citations (Scopus)

Abstract

Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)

Original language	Undefined/Unknown
Pages (from-to)	656-665
Number of pages	10
Journal	Circulation-cardiovascular genetics
Volume	5
Issue number	6
DOIs	https://doi.org/10.1161/CIRCGENETICS.112.963660
Publication status	Published - 2012

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10.1161/CIRCGENETICS.112.963660

http://hdl.handle.net/1765/69394

Cite this

Gertow, K., Sennblad, B., Strawbridge, RJ., Ohrvik, J., Zabaneh, D., Shah, S., Veglia, F., Fava, C., Kavousi, M., McLachlan, S., Kivimaki, M., Bolton, JL., Folkersen, L., Gigante, B., Leander, K., Vikstrom, M., Larsson, M., Silveira, A., Deanfield, J., ... Hamsten, A. (2012). Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk. Circulation-cardiovascular genetics, 5(6), 656-665. https://doi.org/10.1161/CIRCGENETICS.112.963660

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title = "Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk",

abstract = "Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)",

author = "K Gertow and B Sennblad and RJ Strawbridge and J Ohrvik and D Zabaneh and S Shah and F Veglia and C Fava and Maryam Kavousi and S McLachlan and M Kivimaki and JL Bolton and L Folkersen and B Gigante and K Leander and M Vikstrom and M Larsson and A Silveira and J Deanfield and BF Voight and P Fontanillas and M Sabater-Lleal and GI Colombo and M Kumari and C Langenberg and NJ Wareham and Andr{\'e} Uitterlinden and A Gabrielsen and U Hedin and A Franco-Cereceda and K Nyyssonen and R Rauramaa and TP Tuomainen and K Savonen and AJ Smit and P Giral and E Mannarino and CM Robertson and PJ Talmud and B Hedblad and Bert Hofman and J Erdmann and MP Reilly and CJ O'Donnell and M Farrall and R Clarke and MG Franzosi and U Seedorf and AC Syvanen and GK Hansson and P Eriksson and NJ Samani and H Watkins and JF Price and AD Hingorani and O Melander and JCM Witteman and D Baldassarre and E Tremoli and {de Faire}, U and SE Humphries and A Hamsten",

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Gertow, K, Sennblad, B, Strawbridge, RJ, Ohrvik, J, Zabaneh, D, Shah, S, Veglia, F, Fava, C, Kavousi, M, McLachlan, S, Kivimaki, M, Bolton, JL, Folkersen, L, Gigante, B, Leander, K, Vikstrom, M, Larsson, M, Silveira, A, Deanfield, J, Voight, BF, Fontanillas, P, Sabater-Lleal, M, Colombo, GI, Kumari, M, Langenberg, C, Wareham, NJ, Uitterlinden, A, Gabrielsen, A, Hedin, U, Franco-Cereceda, A, Nyyssonen, K, Rauramaa, R, Tuomainen, TP, Savonen, K, Smit, AJ, Giral, P, Mannarino, E, Robertson, CM, Talmud, PJ, Hedblad, B, Hofman, B, Erdmann, J, Reilly, MP, O'Donnell, CJ, Farrall, M, Clarke, R, Franzosi, MG, Seedorf, U, Syvanen, AC, Hansson, GK, Eriksson, P, Samani, NJ, Watkins, H, Price, JF, Hingorani, AD, Melander, O, Witteman, JCM, Baldassarre, D, Tremoli, E, de Faire, U, Humphries, SE & Hamsten, A 2012, 'Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk', Circulation-cardiovascular genetics, vol. 5, no. 6, pp. 656-665. https://doi.org/10.1161/CIRCGENETICS.112.963660

TY - JOUR

T1 - Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

AU - Gertow, K

AU - Sennblad, B

AU - Strawbridge, RJ

AU - Ohrvik, J

AU - Zabaneh, D

AU - Shah, S

AU - Veglia, F

AU - Fava, C

AU - Kavousi, Maryam

AU - McLachlan, S

AU - Kivimaki, M

AU - Bolton, JL

AU - Folkersen, L

AU - Gigante, B

AU - Leander, K

AU - Vikstrom, M

AU - Larsson, M

AU - Silveira, A

AU - Deanfield, J

AU - Voight, BF

AU - Fontanillas, P

AU - Sabater-Lleal, M

AU - Colombo, GI

AU - Kumari, M

AU - Langenberg, C

AU - Wareham, NJ

AU - Uitterlinden, André

AU - Gabrielsen, A

AU - Hedin, U

AU - Franco-Cereceda, A

AU - Nyyssonen, K

AU - Rauramaa, R

AU - Tuomainen, TP

AU - Savonen, K

AU - Smit, AJ

AU - Giral, P

AU - Mannarino, E

AU - Robertson, CM

AU - Talmud, PJ

AU - Hedblad, B

AU - Hofman, Bert

AU - Erdmann, J

AU - Reilly, MP

AU - O'Donnell, CJ

AU - Farrall, M

AU - Clarke, R

AU - Franzosi, MG

AU - Seedorf, U

AU - Syvanen, AC

AU - Hansson, GK

AU - Eriksson, P

AU - Samani, NJ

AU - Watkins, H

AU - Price, JF

AU - Hingorani, AD

AU - Melander, O

AU - Witteman, JCM

AU - Baldassarre, D

AU - Tremoli, E

AU - de Faire, U

AU - Humphries, SE

AU - Hamsten, A

PY - 2012

Y1 - 2012

N2 - Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)

AB - Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)

U2 - 10.1161/CIRCGENETICS.112.963660

DO - 10.1161/CIRCGENETICS.112.963660

M3 - Article

VL - 5

SP - 656

EP - 665

IS - 6

ER -