Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

K Gertow; B Sennblad; RJ Strawbridge; J Ohrvik; D Zabaneh; S Shah; F Veglia; C Fava; Maryam Kavousi; S McLachlan; M Kivimaki; JL Bolton; L Folkersen; B Gigante; K Leander; M Vikstrom; M Larsson; A Silveira; J Deanfield; BF Voight; P Fontanillas; M Sabater-Lleal; GI Colombo; M Kumari; C Langenberg; NJ Wareham; André Uitterlinden; A Gabrielsen; U Hedin; A Franco-Cereceda; K Nyyssonen; R Rauramaa; TP Tuomainen; K Savonen; AJ Smit; P Giral; E Mannarino; CM Robertson; PJ Talmud; B Hedblad; Bert Hofman; J Erdmann; MP Reilly; CJ O'Donnell; M Farrall; R Clarke; MG Franzosi; U Seedorf; AC Syvanen; GK Hansson; P Eriksson; NJ Samani; H Watkins; JF Price; AD Hingorani; O Melander; JCM Witteman; D Baldassarre; E Tremoli; U de Faire; SE Humphries; A Hamsten

doi:10.1161/CIRCGENETICS.112.963660

Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

K Gertow, B Sennblad, RJ Strawbridge, J Ohrvik, D Zabaneh, S Shah, F Veglia, C Fava, Maryam Kavousi, S McLachlan, M Kivimaki, JL Bolton, L Folkersen, B Gigante, K Leander, M Vikstrom, M Larsson, A Silveira, J Deanfield, BF VoightP Fontanillas, M Sabater-Lleal, GI Colombo, M Kumari, C Langenberg, NJ Wareham, André Uitterlinden, A Gabrielsen, U Hedin, A Franco-Cereceda, K Nyyssonen, R Rauramaa, TP Tuomainen, K Savonen, AJ Smit, P Giral, E Mannarino, CM Robertson, PJ Talmud, B Hedblad, Bert Hofman, J Erdmann, MP Reilly, CJ O'Donnell, M Farrall, R Clarke, MG Franzosi, U Seedorf, AC Syvanen, GK Hansson, P Eriksson, NJ Samani, H Watkins, JF Price, AD Hingorani, O Melander, JCM Witteman, D Baldassarre, E Tremoli, U de Faire, SE Humphries, A Hamsten

Research output: Contribution to journal › Article › Academic

31 Citations (Scopus)

Abstract

Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)

Original language	Undefined/Unknown
Pages (from-to)	656-665
Number of pages	10
Journal	Circulation-cardiovascular genetics
Volume	5
Issue number	6
DOIs	https://doi.org/10.1161/CIRCGENETICS.112.963660
Publication status	Published - 2012

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10.1161/CIRCGENETICS.112.963660

http://hdl.handle.net/1765/69394

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Gertow, K., Sennblad, B., Strawbridge, RJ., Ohrvik, J., Zabaneh, D., Shah, S., Veglia, F., Fava, C., Kavousi, M., McLachlan, S., Kivimaki, M., Bolton, JL., Folkersen, L., Gigante, B., Leander, K., Vikstrom, M., Larsson, M., Silveira, A., Deanfield, J., ... Hamsten, A. (2012). Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk. Circulation-cardiovascular genetics, 5(6), 656-665. https://doi.org/10.1161/CIRCGENETICS.112.963660

Gertow, K ; Sennblad, B ; Strawbridge, RJ ; Ohrvik, J ; Zabaneh, D ; Shah, S ; Veglia, F ; Fava, C ; Kavousi, Maryam ; McLachlan, S ; Kivimaki, M ; Bolton, JL ; Folkersen, L ; Gigante, B ; Leander, K ; Vikstrom, M ; Larsson, M ; Silveira, A ; Deanfield, J ; Voight, BF ; Fontanillas, P ; Sabater-Lleal, M ; Colombo, GI ; Kumari, M ; Langenberg, C ; Wareham, NJ ; Uitterlinden, André ; Gabrielsen, A ; Hedin, U ; Franco-Cereceda, A ; Nyyssonen, K ; Rauramaa, R ; Tuomainen, TP ; Savonen, K ; Smit, AJ ; Giral, P ; Mannarino, E ; Robertson, CM ; Talmud, PJ ; Hedblad, B ; Hofman, Bert ; Erdmann, J ; Reilly, MP ; O'Donnell, CJ ; Farrall, M ; Clarke, R ; Franzosi, MG ; Seedorf, U ; Syvanen, AC ; Hansson, GK ; Eriksson, P ; Samani, NJ ; Watkins, H ; Price, JF ; Hingorani, AD ; Melander, O ; Witteman, JCM ; Baldassarre, D ; Tremoli, E ; de Faire, U ; Humphries, SE ; Hamsten, A. / Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk. In: Circulation-cardiovascular genetics. 2012 ; Vol. 5, No. 6. pp. 656-665.

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title = "Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk",

abstract = "Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)",

author = "K Gertow and B Sennblad and RJ Strawbridge and J Ohrvik and D Zabaneh and S Shah and F Veglia and C Fava and Maryam Kavousi and S McLachlan and M Kivimaki and JL Bolton and L Folkersen and B Gigante and K Leander and M Vikstrom and M Larsson and A Silveira and J Deanfield and BF Voight and P Fontanillas and M Sabater-Lleal and GI Colombo and M Kumari and C Langenberg and NJ Wareham and Andr{\'e} Uitterlinden and A Gabrielsen and U Hedin and A Franco-Cereceda and K Nyyssonen and R Rauramaa and TP Tuomainen and K Savonen and AJ Smit and P Giral and E Mannarino and CM Robertson and PJ Talmud and B Hedblad and Bert Hofman and J Erdmann and MP Reilly and CJ O'Donnell and M Farrall and R Clarke and MG Franzosi and U Seedorf and AC Syvanen and GK Hansson and P Eriksson and NJ Samani and H Watkins and JF Price and AD Hingorani and O Melander and JCM Witteman and D Baldassarre and E Tremoli and {de Faire}, U and SE Humphries and A Hamsten",

year = "2012",

doi = "10.1161/CIRCGENETICS.112.963660",

language = "Undefined/Unknown",

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Gertow, K, Sennblad, B, Strawbridge, RJ, Ohrvik, J, Zabaneh, D, Shah, S, Veglia, F, Fava, C, Kavousi, M, McLachlan, S, Kivimaki, M, Bolton, JL, Folkersen, L, Gigante, B, Leander, K, Vikstrom, M, Larsson, M, Silveira, A, Deanfield, J, Voight, BF, Fontanillas, P, Sabater-Lleal, M, Colombo, GI, Kumari, M, Langenberg, C, Wareham, NJ, Uitterlinden, A, Gabrielsen, A, Hedin, U, Franco-Cereceda, A, Nyyssonen, K, Rauramaa, R, Tuomainen, TP, Savonen, K, Smit, AJ, Giral, P, Mannarino, E, Robertson, CM, Talmud, PJ, Hedblad, B, Hofman, B, Erdmann, J, Reilly, MP, O'Donnell, CJ, Farrall, M, Clarke, R, Franzosi, MG, Seedorf, U, Syvanen, AC, Hansson, GK, Eriksson, P, Samani, NJ, Watkins, H, Price, JF, Hingorani, AD, Melander, O, Witteman, JCM, Baldassarre, D, Tremoli, E, de Faire, U, Humphries, SE & Hamsten, A 2012, 'Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk', Circulation-cardiovascular genetics, vol. 5, no. 6, pp. 656-665. https://doi.org/10.1161/CIRCGENETICS.112.963660

Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk. / Gertow, K; Sennblad, B; Strawbridge, RJ; Ohrvik, J; Zabaneh, D; Shah, S; Veglia, F; Fava, C; Kavousi, Maryam; McLachlan, S; Kivimaki, M; Bolton, JL; Folkersen, L; Gigante, B; Leander, K; Vikstrom, M; Larsson, M; Silveira, A; Deanfield, J; Voight, BF; Fontanillas, P; Sabater-Lleal, M; Colombo, GI; Kumari, M; Langenberg, C; Wareham, NJ; Uitterlinden, André; Gabrielsen, A; Hedin, U; Franco-Cereceda, A; Nyyssonen, K; Rauramaa, R; Tuomainen, TP; Savonen, K; Smit, AJ; Giral, P; Mannarino, E; Robertson, CM; Talmud, PJ; Hedblad, B; Hofman, Bert; Erdmann, J; Reilly, MP; O'Donnell, CJ; Farrall, M; Clarke, R; Franzosi, MG; Seedorf, U; Syvanen, AC; Hansson, GK; Eriksson, P; Samani, NJ; Watkins, H; Price, JF; Hingorani, AD; Melander, O; Witteman, JCM; Baldassarre, D; Tremoli, E; de Faire, U; Humphries, SE; Hamsten, A.

In: Circulation-cardiovascular genetics, Vol. 5, No. 6, 2012, p. 656-665.

Research output: Contribution to journal › Article › Academic

TY - JOUR

T1 - Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

AU - Gertow, K

AU - Sennblad, B

AU - Strawbridge, RJ

AU - Ohrvik, J

AU - Zabaneh, D

AU - Shah, S

AU - Veglia, F

AU - Fava, C

AU - Kavousi, Maryam

AU - McLachlan, S

AU - Kivimaki, M

AU - Bolton, JL

AU - Folkersen, L

AU - Gigante, B

AU - Leander, K

AU - Vikstrom, M

AU - Larsson, M

AU - Silveira, A

AU - Deanfield, J

AU - Voight, BF

AU - Fontanillas, P

AU - Sabater-Lleal, M

AU - Colombo, GI

AU - Kumari, M

AU - Langenberg, C

AU - Wareham, NJ

AU - Uitterlinden, André

AU - Gabrielsen, A

AU - Hedin, U

AU - Franco-Cereceda, A

AU - Nyyssonen, K

AU - Rauramaa, R

AU - Tuomainen, TP

AU - Savonen, K

AU - Smit, AJ

AU - Giral, P

AU - Mannarino, E

AU - Robertson, CM

AU - Talmud, PJ

AU - Hedblad, B

AU - Hofman, Bert

AU - Erdmann, J

AU - Reilly, MP

AU - O'Donnell, CJ

AU - Farrall, M

AU - Clarke, R

AU - Franzosi, MG

AU - Seedorf, U

AU - Syvanen, AC

AU - Hansson, GK

AU - Eriksson, P

AU - Samani, NJ

AU - Watkins, H

AU - Price, JF

AU - Hingorani, AD

AU - Melander, O

AU - Witteman, JCM

AU - Baldassarre, D

AU - Tremoli, E

AU - de Faire, U

AU - Humphries, SE

AU - Hamsten, A

PY - 2012

Y1 - 2012

N2 - Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)

AB - Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinations of cIMT from the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. Segment-specific IMT measurements of common carotid, bifurcation, and internal carotid arteries, and composite IMT variables c Conclusions-This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of cIMT and coronary artery disease risk in individuals of European descent. (Circ Cardiovasc Genet. 2012;5:656-665.)

U2 - 10.1161/CIRCGENETICS.112.963660

DO - 10.1161/CIRCGENETICS.112.963660

M3 - Article

VL - 5

SP - 656

EP - 665

IS - 6

ER -