TY - JOUR
T1 - IL-15 in HIV infection
T2 - pathogenic or therapeutic potential?
AU - Mueller, Yvonne M
AU - Katsikis, Peter D
PY - 2010/9
Y1 - 2010/9
N2 - Recent studies have shown that interleukin-15 (IL-15) is produced during acute HIV and SIV infection, and may impact viremia and viral set point. This is further supported by the findings that administration of IL-15 during acute SIV infection dramatically increases viral set point. Although the role of intrinsic IL-15 during chronic infection is much less defined, in vivo administration of IL-15 does not increase viral replication in SIV-infected animals. Recent data also suggest that IL-15 acts, not only on CD8+ T cells and natural killer cells, but also on effector memory CD4+ T cells. IL-15 clearly expands very different CD4+ T cell subpopulations than IL-2 in SIV-infected animals, and may be useful for the restoration of effector memory CD4+ T cells that are depleted early in HIV and SIV infection. Understanding IL-15' s role in SIV infection may help us to design novel therapeutic approaches to HIV infection.
AB - Recent studies have shown that interleukin-15 (IL-15) is produced during acute HIV and SIV infection, and may impact viremia and viral set point. This is further supported by the findings that administration of IL-15 during acute SIV infection dramatically increases viral set point. Although the role of intrinsic IL-15 during chronic infection is much less defined, in vivo administration of IL-15 does not increase viral replication in SIV-infected animals. Recent data also suggest that IL-15 acts, not only on CD8+ T cells and natural killer cells, but also on effector memory CD4+ T cells. IL-15 clearly expands very different CD4+ T cell subpopulations than IL-2 in SIV-infected animals, and may be useful for the restoration of effector memory CD4+ T cells that are depleted early in HIV and SIV infection. Understanding IL-15' s role in SIV infection may help us to design novel therapeutic approaches to HIV infection.
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:000281962000011&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1684/ecn.2010.0198
DO - 10.1684/ecn.2010.0198
M3 - Article
C2 - 20719708
SN - 1148-5493
VL - 21
SP - 219
EP - 221
JO - European Cytokine Network
JF - European Cytokine Network
IS - 3
ER -