IL-6-induced anaemia in rats: Possible pathogenetic implications for anaemia observed in chronic inflammations

M. Jongen-Lavrencic; H. R.M. Peeters; H. Rozemuller; W. J.C. Rombouts; A. C.M. Martens; G. Vreugdenhil; M. Pillay; P. H. Cox; M. Bijser; G. Brutel; F. C. Breedveld; A. J.G. Swaak

doi:10.1046/j.1365-2249.1996.d01-622.x

IL-6-induced anaemia in rats: Possible pathogenetic implications for anaemia observed in chronic inflammations

M. Jongen-Lavrencic
, H. R.M. Peeters
, H. Rozemuller
, W. J.C. Rombouts
, A. C.M. Martens
, G. Vreugdenhil
, M. Pillay
, P. H. Cox
, M. Bijser
, G. Brutel
, F. C. Breedveld
, A. J.G. Swaak^*

^*Corresponding author for this work

Daniel den Hoed Clinic
Sint Josephziekenhuis (Veldhoven)
Leiden University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-α), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 in the pathogenesis of this anaemia was investigated. IL-6 was administered intraperitoneally to rats for 14 sequential days. It appeared that IL-6 was able to induce anaemia. No evidence for suppression of bone marrow erythropoiesis or enhanced sequestration of erythrocytes in the liver was found. However, decreased plasma and bone marrow iron contents were observed in anaemic rats. Blood loss in intestinal tissue was demonstrated using erythrocyte labelling with ^99mtechnetium. Histologically this was associated with inflammatory cell infiltration, oedema and bleeding in the intestinal wall. In conclusion, IL-6 induced anaemia in rats. This anaemia was caused by intestinal blood loss.

Original language	English
Pages (from-to)	328-334
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2249.1996.d01-622.x
Publication status	Published - Feb 1996

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Jongen-Lavrencic, M., Peeters, H. R. M., Rozemuller, H., Rombouts, W. J. C., Martens, A. C. M., Vreugdenhil, G., Pillay, M., Cox, P. H., Bijser, M., Brutel, G., Breedveld, F. C., & Swaak, A. J. G. (1996). IL-6-induced anaemia in rats: Possible pathogenetic implications for anaemia observed in chronic inflammations. Clinical and Experimental Immunology, 103(2), 328-334. https://doi.org/10.1046/j.1365-2249.1996.d01-622.x

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title = "IL-6-induced anaemia in rats: Possible pathogenetic implications for anaemia observed in chronic inflammations",

abstract = "Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-α), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 in the pathogenesis of this anaemia was investigated. IL-6 was administered intraperitoneally to rats for 14 sequential days. It appeared that IL-6 was able to induce anaemia. No evidence for suppression of bone marrow erythropoiesis or enhanced sequestration of erythrocytes in the liver was found. However, decreased plasma and bone marrow iron contents were observed in anaemic rats. Blood loss in intestinal tissue was demonstrated using erythrocyte labelling with 99mtechnetium. Histologically this was associated with inflammatory cell infiltration, oedema and bleeding in the intestinal wall. In conclusion, IL-6 induced anaemia in rats. This anaemia was caused by intestinal blood loss.",

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Jongen-Lavrencic, M, Peeters, HRM, Rozemuller, H, Rombouts, WJC, Martens, ACM, Vreugdenhil, G, Pillay, M, Cox, PH, Bijser, M, Brutel, G, Breedveld, FC & Swaak, AJG 1996, 'IL-6-induced anaemia in rats: Possible pathogenetic implications for anaemia observed in chronic inflammations', Clinical and Experimental Immunology, vol. 103, no. 2, pp. 328-334. https://doi.org/10.1046/j.1365-2249.1996.d01-622.x

TY - JOUR

T1 - IL-6-induced anaemia in rats

T2 - Possible pathogenetic implications for anaemia observed in chronic inflammations

AU - Jongen-Lavrencic, M.

AU - Peeters, H. R.M.

AU - Rozemuller, H.

AU - Rombouts, W. J.C.

AU - Martens, A. C.M.

AU - Vreugdenhil, G.

AU - Pillay, M.

AU - Cox, P. H.

AU - Bijser, M.

AU - Brutel, G.

AU - Breedveld, F. C.

AU - Swaak, A. J.G.

PY - 1996/2

Y1 - 1996/2

N2 - Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-α), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 in the pathogenesis of this anaemia was investigated. IL-6 was administered intraperitoneally to rats for 14 sequential days. It appeared that IL-6 was able to induce anaemia. No evidence for suppression of bone marrow erythropoiesis or enhanced sequestration of erythrocytes in the liver was found. However, decreased plasma and bone marrow iron contents were observed in anaemic rats. Blood loss in intestinal tissue was demonstrated using erythrocyte labelling with 99mtechnetium. Histologically this was associated with inflammatory cell infiltration, oedema and bleeding in the intestinal wall. In conclusion, IL-6 induced anaemia in rats. This anaemia was caused by intestinal blood loss.

AB - Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-α), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 in the pathogenesis of this anaemia was investigated. IL-6 was administered intraperitoneally to rats for 14 sequential days. It appeared that IL-6 was able to induce anaemia. No evidence for suppression of bone marrow erythropoiesis or enhanced sequestration of erythrocytes in the liver was found. However, decreased plasma and bone marrow iron contents were observed in anaemic rats. Blood loss in intestinal tissue was demonstrated using erythrocyte labelling with 99mtechnetium. Histologically this was associated with inflammatory cell infiltration, oedema and bleeding in the intestinal wall. In conclusion, IL-6 induced anaemia in rats. This anaemia was caused by intestinal blood loss.

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SN - 0009-9104

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SP - 328

EP - 334

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -

IL-6-induced anaemia in rats: Possible pathogenetic implications for anaemia observed in chronic inflammations

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