Image-guided drug delivery in nanosystem-based cancer therapies

Marjolein I. Priester, Timo L.M. Ten Hagen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The past decades have shown significant advancements in the development of solid tumor treatment. For instance, implementation of nanosystems for drug delivery has led to a reduction in side effects and improved delivery to the tumor region. However, clinical translation has faced challenges, as tumor drug levels are still considered to be inadequate. Interdisciplinary research has resulted in the development of more advanced drug delivery systems. These are coined "smart" due to the ability to be followed and actively manipulated in order to have better control over local drug release. Therefore, image-guided drug delivery can be a powerful strategy to improve drug activity at the target site. Being able to visualize the inflow of the administered smart nanosystem within the tumor gives the potential to determine the right moment to apply the facilitator to initiate drug release. Here we provide an overview of available nanosystems, imaging moieties, and imaging techniques. We discuss preclinical application of these smart drug delivery systems, the strength of image-guided drug delivery, and the future of personalized treatment.

Original languageEnglish
Article number114621
Number of pages1
JournalAdvanced Drug Delivery Reviews
Volume192
DOIs
Publication statusPublished - Jan 2023

Bibliographical note

Publisher Copyright:
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

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