Imaging atherosclerotic plaque composition with intracoronary optical coherence tomography

Gijs van Soest, TPM Goderie, Nieves Gonzalo Lopez, Senada Koljenovic, Arno van Leenders, Evelyn Regar, PWJC (Patrick) Serruys, Ton van der Steen

Research output: Contribution to journalArticleAcademic

12 Citations (Scopus)


Optical coherence tomography (OCT) allows highly accurate diagnosis of atherosclerotic plaques, including measurement of the thickness of fibrous caps, permitting an assessment of the risk of rupture. While the OCT image presents morphological information in highly resolved detail, it relies on interpretation by trained readers for the identification of tissue type. We developed a method for quantitative classification of atherosclerotic plaque constituents. The optical attenuation coefficient It, distinguishes different tissue types: necrotic core and macrophage infiltration exhibit strong attenuation, mu(t)>= 10 mm(-1), while calcific and fibrous tissue have a lower mu(t)approximate to 2-5 mm(-1). (Neth Heart J 2009;17:448-50.)
Original languageUndefined/Unknown
Pages (from-to)448-450
Number of pages3
JournalCardiologie (Hoogland)
Issue number11
Publication statusPublished - 2009

Research programs

  • EMC COEUR-09
  • EMC MM-03-24-01

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