Immune and neuroimmune alterations in mood disorders and schizophrenia

Roosmarijn Drexhage; Karin Weigelt; JM Beveren; D Cohen; Marjan Versnel; WA Nolen; Hemmo Drexhage

doi:10.1016/B978-0-12-387718-5.00007-9

Immune and neuroimmune alterations in mood disorders and schizophrenia

Roosmarijn Drexhage, Karin Weigelt, JM Beveren, D Cohen, Marjan Versnel, WA Nolen, Hemmo Drexhage

Research output: Contribution to journal › Article › Academic › peer-review

63 Citations (Scopus)

Abstract

A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.

Original language	Undefined/Unknown
Pages (from-to)	169-201
Number of pages	33
Journal	International Review of Neurobiology
Volume	101
DOIs	https://doi.org/10.1016/B978-0-12-387718-5.00007-9
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-387718-5.00007-9

http://hdl.handle.net/1765/56144

Cite this

@article{411b21437e9f4c22b9f9ebc28dcb3000,

title = "Immune and neuroimmune alterations in mood disorders and schizophrenia",

abstract = "A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.",

author = "Roosmarijn Drexhage and Karin Weigelt and JM Beveren and D Cohen and Marjan Versnel and WA Nolen and Hemmo Drexhage",

year = "2011",

doi = "10.1016/B978-0-12-387718-5.00007-9",

language = "Undefined/Unknown",

volume = "101",

pages = "169--201",

journal = "International Review of Neurobiology",

issn = "0074-7742",

publisher = "Academic Press",

}

TY - JOUR

T1 - Immune and neuroimmune alterations in mood disorders and schizophrenia

AU - Drexhage, Roosmarijn

AU - Weigelt, Karin

AU - Beveren, JM

AU - Cohen, D

AU - Versnel, Marjan

AU - Nolen, WA

AU - Drexhage, Hemmo

PY - 2011

Y1 - 2011

N2 - A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.

AB - A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.

U2 - 10.1016/B978-0-12-387718-5.00007-9

DO - 10.1016/B978-0-12-387718-5.00007-9

M3 - Article

SN - 0074-7742

VL - 101

SP - 169

EP - 201

JO - International Review of Neurobiology

JF - International Review of Neurobiology

ER -