Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases

Ton Langerak, F Davi, P Ghia, A Hadzidimitriou, F Murray, KN Potter, R Rosenquist, K Stamatopoulos, C Belessi

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Abstract

prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011
Original languageUndefined/Unknown
Pages (from-to)979-984
Number of pages6
JournalLeukemia
Volume25
Issue number6
DOIs
Publication statusPublished - 2011

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