Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases

Ton Langerak; F Davi; P Ghia; A Hadzidimitriou; F Murray; KN Potter; R Rosenquist; K Stamatopoulos; C Belessi

doi:10.1038/leu.2011.49

Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases

Ton Langerak
, F Davi
, P Ghia
, A Hadzidimitriou
, F Murray
, KN Potter
, R Rosenquist
, K Stamatopoulos
, C Belessi

Immunology

Research output: Contribution to journal › Article › Academic › peer-review

71 Citations (Scopus)

Abstract

prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011

Original language	Undefined/Unknown
Pages (from-to)	979-984
Number of pages	6
Journal	Leukemia
Volume	25
Issue number	6
DOIs	https://doi.org/10.1038/leu.2011.49
Publication status	Published - 2011

Research programs

EMC MM-02-72-01

Access to Document

10.1038/leu.2011.49

http://hdl.handle.net/1765/26152

Cite this

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title = "Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases",

abstract = "prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011",

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AU - Langerak, Ton

AU - Davi, F

AU - Ghia, P

AU - Hadzidimitriou, A

AU - Murray, F

AU - Potter, KN

AU - Rosenquist, R

AU - Stamatopoulos, K

AU - Belessi, C

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AB - prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011

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