Immunological function of tubular epithelial cells: The functional implications of CD40 expression

Cees Van Kooten; Andrea M. Woltman; Mohamed R. Daha

doi:10.1159/000020669

Immunological function of tubular epithelial cells: The functional implications of CD40 expression

Cees Van Kooten^*, Andrea M. Woltman, Mohamed R. Daha

^*Corresponding author for this work

Leiden University Medical Centre

Research output: Contribution to journal › Short survey › Academic › peer-review

37 Citations (Scopus)

Abstract

Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40. In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function. Copyright (C) 2000 S. Karger AG, Basel.

Original language	English
Pages (from-to)	203-207
Number of pages	5
Journal	Experimental Nephrology
Volume	8
Issue number	4-5
DOIs	https://doi.org/10.1159/000020669
Publication status	Published - 2000
Externally published	Yes

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title = "Immunological function of tubular epithelial cells: The functional implications of CD40 expression",

abstract = "Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40. In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function. Copyright (C) 2000 S. Karger AG, Basel.",

author = "\{Van Kooten\}, Cees and Woltman, \{Andrea M.\} and Daha, \{Mohamed R.\}",

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doi = "10.1159/000020669",

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journal = "Experimental Nephrology",

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T2 - The functional implications of CD40 expression

AU - Van Kooten, Cees

AU - Woltman, Andrea M.

AU - Daha, Mohamed R.

PY - 2000

Y1 - 2000

N2 - Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40. In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function. Copyright (C) 2000 S. Karger AG, Basel.

AB - Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40. In the present review we will discuss the potential implications of CD40-CD40L interactions for the activation of TECs and its immunological function. Copyright (C) 2000 S. Karger AG, Basel.

UR - https://www.scopus.com/pages/publications/0033840008

U2 - 10.1159/000020669

DO - 10.1159/000020669

M3 - Short survey

C2 - 10940717

AN - SCOPUS:0033840008

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VL - 8

SP - 203

EP - 207

JO - Experimental Nephrology

JF - Experimental Nephrology

IS - 4-5

ER -

Immunological function of tubular epithelial cells: The functional implications of CD40 expression

Abstract

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