Abstract
Paraneoplastic neurological syndromes are believed to result from ectopic expression of onconeural antigens by tumours. The resulting immune response is not only directed against the tumour but also cross-reacts with the same or similar antigens in the nervous system.
- The immune response generates high titred autoantibodies that are associated with specific turnouts and neurological syndromes.
- Paraneoplastic autoantibodies help diagnose neurological syndromes and help direct the search for an underlying tumour.
- In paraneoplastic syndromes, the course of the turnout is relatively mild.
- Detection of the autoantibodies might lead to early diagnosis and immunomodulation and anti-tumour treatment before irreversible neuronal cell loss and deficits set in.
- The immune response generates high titred autoantibodies that are associated with specific turnouts and neurological syndromes.
- Paraneoplastic autoantibodies help diagnose neurological syndromes and help direct the search for an underlying tumour.
- In paraneoplastic syndromes, the course of the turnout is relatively mild.
- Detection of the autoantibodies might lead to early diagnosis and immunomodulation and anti-tumour treatment before irreversible neuronal cell loss and deficits set in.
| Translated title of the contribution | Immunology in clinical practice XVI. Paraneoplastic syndromes of the nervous system: Pathogenesis and diagnosis |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 1652-1658 |
| Number of pages | 7 |
| Journal | Nederlands Tijdschrift voor Geneeskunde |
| Volume | 142 |
| Issue number | 29 |
| Publication status | Published - 22 Jul 1998 |
Research programs
- EMC 04-01-DD-06-01
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