TY - JOUR
T1 - Impact of contrast material volume on quantitative assessment of reperfused acute myocardial infarction using delayed-enhancement 64-slice CT: experience in a porcine model
AU - Martini, C
AU - Maffei, E
AU - Palumbo, AA
AU - Weustink, A.C.
AU - Baks, Timo
AU - Moelker, Adriaan
AU - Dunker, D
AU - Emiliano, E
AU - Cuttone, A
AU - Mollet, Nico
AU - Krestin, Gabriel
AU - Feijter, Pim
AU - Cademartiri, F.
PY - 2010
Y1 - 2010
N2 - Purpose. Our purpose in this study was to compare the impact of contrast material volume in delayed-enhancement computer tomography (CT) imaging for assessing acute reperfused myocardial infarction. Materials and methods. In five domestic pigs (20-30 kg) the circumflex coronary artery (CX) was balloon-occluded for 2 h followed by reperfusion. After 5 days, CT imaging was performed after intravenous administration of iodinated contrast material (Iomeprol 400mgI/ml; Bracco, Italy). A 64-slice multidetector CT (MDCT) (Sensation 64, Siemens) scanner was used for imaging, with standard angiography characteristics. Three scans were performed: first, coronary angiography at first pass with 1.25 gl/kg of contrast material (ART); and remaining delayedenhancement (DE1-DE2) 15 min after administration of 1.25 (DE1) and 15 min after additional administration of 2.50 gI/kg (=total 3.75 gI/kg - DE2). Mean heart rate decreased to 51 +/- 9 bpm after intravenous administration of Zatebradine (10 mg/kg). Data sets were reconstructed during the end-diastolic phase of the cardiac cycle. Areas of infarction-enhanced (DE), no-reflow (no-reflow) and remote myocardial [remote left ventricle (LV)] were manually contoured. CT attenuation values (Hounsfield units) were measured using five regions of interest: DE, no-reflow, remote LV, left ventricular cavity (lumen LV) and in air. Differences, correlations, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Results. We found significant differences between the attenuation of DE, no-reflow and remote LV (p<0.001). DE and no-reflow size were assessed accurately with DE-MDCT. In particular, SNR and CNR showed higher values in DE2 (similar to 6.0 and 3.5, respectively; r(2)=0.90) vs. DE1 (similar to 4.0 and 2.2, respectively; r(2)=0.85). Conclusions. The increase of contrast material volume determines a significant improvement in myocardial infarction image quality with DE-MDCT.
AB - Purpose. Our purpose in this study was to compare the impact of contrast material volume in delayed-enhancement computer tomography (CT) imaging for assessing acute reperfused myocardial infarction. Materials and methods. In five domestic pigs (20-30 kg) the circumflex coronary artery (CX) was balloon-occluded for 2 h followed by reperfusion. After 5 days, CT imaging was performed after intravenous administration of iodinated contrast material (Iomeprol 400mgI/ml; Bracco, Italy). A 64-slice multidetector CT (MDCT) (Sensation 64, Siemens) scanner was used for imaging, with standard angiography characteristics. Three scans were performed: first, coronary angiography at first pass with 1.25 gl/kg of contrast material (ART); and remaining delayedenhancement (DE1-DE2) 15 min after administration of 1.25 (DE1) and 15 min after additional administration of 2.50 gI/kg (=total 3.75 gI/kg - DE2). Mean heart rate decreased to 51 +/- 9 bpm after intravenous administration of Zatebradine (10 mg/kg). Data sets were reconstructed during the end-diastolic phase of the cardiac cycle. Areas of infarction-enhanced (DE), no-reflow (no-reflow) and remote myocardial [remote left ventricle (LV)] were manually contoured. CT attenuation values (Hounsfield units) were measured using five regions of interest: DE, no-reflow, remote LV, left ventricular cavity (lumen LV) and in air. Differences, correlations, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Results. We found significant differences between the attenuation of DE, no-reflow and remote LV (p<0.001). DE and no-reflow size were assessed accurately with DE-MDCT. In particular, SNR and CNR showed higher values in DE2 (similar to 6.0 and 3.5, respectively; r(2)=0.90) vs. DE1 (similar to 4.0 and 2.2, respectively; r(2)=0.85). Conclusions. The increase of contrast material volume determines a significant improvement in myocardial infarction image quality with DE-MDCT.
U2 - 10.1007/s11547-009-0481-8
DO - 10.1007/s11547-009-0481-8
M3 - Article
C2 - 20017004
SN - 0033-8362
VL - 115
SP - 22
EP - 35
JO - Radiologia Medica
JF - Radiologia Medica
IS - 1
ER -