@article{6eb02151710048e68e3e73ae9d36582e,
title = "Impact of haemolysis on vancomycin disposition in a full-term neonate treated with extracorporeal membrane oxygenation",
abstract = "Introduction: Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. Pharmacological consequences of ECMO-induced haemolysis in neonates are not well understood. Case report: We report a case report of a full-term neonate treated for congenital diaphragmatic hernia and sepsis with ECMO and with vancomycin. While the population elimination half-life of 7 h was estimated, fitting of the simulated population pharmacokinetic profile to truly observed drug concentration points resulted in the personalized value of 41 h. Discussion: The neonate developed ECMO-induced haemolysis with subsequent acute kidney injury resulting in prolonged drug elimination. Whole blood/serum ratio of 0.79 excluded possibility of direct increase of vancomycin serum concentration during haemolysis. Conclusion: Vancomycin elimination may be severely prolonged due to ECMO-induced haemolysis and acute kidney injury, while hypothesis of direct increase of vancomycin levels by releasing the drug from blood cells during haemolysis has been disproved.",
author = "Pavla Pokorn{\'a} and Martin {\v S}{\'i}ma and Dick Tibboel and Ond{\v r}ej Slana{\v r}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the project MH CZ-DRO-VFN64165 in the Czech Republic, by the Charles University project PROGRES Q25/LF1 and SVV 260523, by an unrestricted research grant of the Intensive Care Unit of the ErasmusMC-Sophia Children?s Hospital, and by the project UNCE204064 (the Innovative Medicines Initiative 2, grant agreement No 777389 from the European Union?s Horizon 2020 and EFPIA). Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the project MH CZ-DRO-VFN64165 in the Czech Republic, by the Charles University project PROGRES Q25/LF1 and SVV 260523, by an unrestricted research grant of the Intensive Care Unit of the ErasmusMC-Sophia Children{\textquoteright}s Hospital, and by the project UNCE204064 (the Innovative Medicines Initiative 2, grant agreement No 777389 from the European Union{\textquoteright}s Horizon 2020 and EFPIA). Publisher Copyright: {\textcopyright} The Author(s) 2020.",
year = "2021",
month = nov,
doi = "10.1177/0267659120973595",
language = "English",
volume = "36",
pages = "864--867",
journal = "Perfusion (United Kingdom)",
issn = "0267-6591",
publisher = "SAGE Publications Ltd",
number = "8",
}