Implementation of Pericytes in Vascular Regeneration Strategies

Elana M. Meijer, Christian G. M. van Dijk, Rafael Kramann, Marianne C. Verhaar, Caroline Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)

Abstract

For the survival and integration of complex large-sized tissue-engineered (TE) organ constructs that exceed the maximal nutrients and oxygen diffusion distance required for cell survival, graft (pre)vascularization to ensure medium or blood supply is crucial. To achieve this, the morphology and functionality of the microcapillary bed should be mimicked by incorporating vascular cell populations, including endothelium and mural cells. Pericytes play a crucial role in microvascular function, blood vessel stability, angiogenesis, and blood pressure regulation. In addition, tissue-specific pericytes are important in maintaining specific functions in different organs, including vitamin A storage in the liver, renin production in the kidneys and maintenance of the blood-brain-barrier. Together with their multipotential differentiation capacity, this makes pericytes the preferred cell type for application in TE grafts. The use of a tissue-specific pericyte cell population that matches the TE organ may benefit organ function. In this review, we provide an overview of the literature for graft (pre)-vascularization strategies and highlight the possible advantages of using tissue-specific pericytes for specific TE organ grafts.Impact statementThe use of a tissue-specific pericyte cell population that matches the tissue-engineered (TE) organ may benefit organ function. In this review, we provide an overview of the literature for graft (pre)vascularization strategies and highlight the possible advantages of using tissue-specific pericytes for specific TE organ grafts.
Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalTissue Engineering - Part B: Reviews
Volume28
Issue number1
Early online date20 Jan 2021
DOIs
Publication statusPublished - 15 Feb 2022

Bibliographical note

Funding Information
This work was supported by Netherlands Foundation for Cardiovascular Excellence (Caroline Cheng), Netherlands Organization for Scientific Research Vidi grant (No. 91714302 to Caroline Cheng) and Material Driven Regeneration Consortium (Gravitation program to Caroline Cheng and Marianne C. Verhaar), the Erasmus MC fellowship grant (Caroline Cheng), the Regenerative Medicine Fellowship grant of the University Medical Center Utrecht (Caroline Cheng), the Netherlands Cardiovascular Research Initiative: An initiative with support of the Dutch Heart Foundation (CVON2014-11 RECONNECT to Caroline Cheng and Marianne C. Verhaar), and the RECONNECT young talent grant (CVON2014-11 RECONNECT to Christian G.M. van Dijk).

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