Improved early diagnosis of adult polycystic kidney disease with flanking DNA markers

M. H. Breuning; H. Brunner; J. J. Saris; G. J.B. Van Ommen; S. T. Reeders; J. W. Ijdo; A. Verwest; P. L. Pearson

doi:10.1016/S0140-6736(87)91256-6

Improved early diagnosis of adult polycystic kidney disease with flanking DNA markers

M. H. Breuning^*
, H. Brunner
, J. J. Saris
, G. J.B. Van Ommen
, S. T. Reeders
, J. W. Ijdo
, A. Verwest
, P. L. Pearson

^*Corresponding author for this work

Leiden University
Radboud University Nijmegen
John Radcliffe Hospital
Leiden University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

79 Citations (Scopus)

Abstract

A new polymorphic DNA marker for the diagnosis of autosomal dominant adult polycystic kidney disease (APKD) has been identified. The new marker, 24-1, flanks the APKD gene on the side opposite to the alpha globin on the short arm of chromosome 16. When both DNA polymorphisms bracketing the gene are informative the reliability of prenatal and presymptom diagnosis of polycystic kidney disease in non-recombinants (92% of cases) is more than 99%.

Original language	English
Pages (from-to)	1359-1361
Number of pages	3
Journal	The Lancet
Volume	330
Issue number	8572
DOIs	https://doi.org/10.1016/S0140-6736(87)91256-6
Publication status	Published - 12 Dec 1987
Externally published	Yes

Bibliographical note

Funding Information: The studies were financed by the Netherlands Kidney Foundation.

Access to Document

10.1016/S0140-6736(87)91256-6

Cite this

@article{6857db8f00bd499d8a16495c05ad67b5,

title = "Improved early diagnosis of adult polycystic kidney disease with flanking DNA markers",

abstract = "A new polymorphic DNA marker for the diagnosis of autosomal dominant adult polycystic kidney disease (APKD) has been identified. The new marker, 24-1, flanks the APKD gene on the side opposite to the alpha globin on the short arm of chromosome 16. When both DNA polymorphisms bracketing the gene are informative the reliability of prenatal and presymptom diagnosis of polycystic kidney disease in non-recombinants (92\% of cases) is more than 99\%.",

author = "Breuning, \{M. H.\} and H. Brunner and Saris, \{J. J.\} and \{Van Ommen\}, \{G. J.B.\} and Reeders, \{S. T.\} and Ijdo, \{J. W.\} and A. Verwest and Pearson, \{P. L.\}",

note = "Funding Information: The studies were financed by the Netherlands Kidney Foundation. ",

year = "1987",

month = dec,

day = "12",

doi = "10.1016/S0140-6736(87)91256-6",

language = "English",

volume = "330",

pages = "1359--1361",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier",

number = "8572",

}

TY - JOUR

T1 - Improved early diagnosis of adult polycystic kidney disease with flanking DNA markers

AU - Breuning, M. H.

AU - Brunner, H.

AU - Saris, J. J.

AU - Van Ommen, G. J.B.

AU - Reeders, S. T.

AU - Ijdo, J. W.

AU - Verwest, A.

AU - Pearson, P. L.

N1 - Funding Information: The studies were financed by the Netherlands Kidney Foundation.

PY - 1987/12/12

Y1 - 1987/12/12

N2 - A new polymorphic DNA marker for the diagnosis of autosomal dominant adult polycystic kidney disease (APKD) has been identified. The new marker, 24-1, flanks the APKD gene on the side opposite to the alpha globin on the short arm of chromosome 16. When both DNA polymorphisms bracketing the gene are informative the reliability of prenatal and presymptom diagnosis of polycystic kidney disease in non-recombinants (92% of cases) is more than 99%.

AB - A new polymorphic DNA marker for the diagnosis of autosomal dominant adult polycystic kidney disease (APKD) has been identified. The new marker, 24-1, flanks the APKD gene on the side opposite to the alpha globin on the short arm of chromosome 16. When both DNA polymorphisms bracketing the gene are informative the reliability of prenatal and presymptom diagnosis of polycystic kidney disease in non-recombinants (92% of cases) is more than 99%.

UR - https://www.scopus.com/pages/publications/0023511489

U2 - 10.1016/S0140-6736(87)91256-6

DO - 10.1016/S0140-6736(87)91256-6

M3 - Article

C2 - 2890952

AN - SCOPUS:0023511489

SN - 0140-6736

VL - 330

SP - 1359

EP - 1361

JO - The Lancet

JF - The Lancet

IS - 8572

ER -

Improved early diagnosis of adult polycystic kidney disease with flanking DNA markers

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this