Improved overall survival for patients with rectal cancer since 1990: The effects of TME surgery and pre-operative radiotherapy

M den Dulk; P (Pieta) Krijnen; CAM Marijnen; Riekie Rutten; LV van de Poll-Franse; H Putter; EMK Kranenbarg; MLEA Jansen-Landheer; Jan Willem Coebergh; CJH van de Velde

doi:10.1016/j.ejca.2008.05.004

Improved overall survival for patients with rectal cancer since 1990: The effects of TME surgery and pre-operative radiotherapy

M den Dulk, P (Pieta) Krijnen, CAM Marijnen, Riekie Rutten, LV van de Poll-Franse, H Putter, EMK Kranenbarg, MLEA Jansen-Landheer, Jan Willem Coebergh, CJH van de Velde

Research output: Contribution to journal › Article › Academic › peer-review

88 Citations (Scopus)

Abstract

Aim: The aim was to study the effects of the introduction of TME surgery and pre-operative radiotherapy on overall survival (OS) by comparing patients treated in the period before (1990-1995), during (1996-1999) and after (2000-2002) the TME trial. Patients and methods: Patients diagnosed with rectal carcinoma in the region of Comprehensive Cancer Centres South and West were used (n = 3179). Results: Five-year OS was, respectively, 56%, 62% and 65% in the pre-trial, trial and post-trial periods (p < 0.001). Pre-operative RT was increasingly used over time and significantly related to OS in the post-trial period (p = 0.002), but not in the pre-trial and trial periods. Conclusions: Population-based OS improved markedly since the introduction of TME surgery. With standardised TME surgery, pre-operative RT improved OS, whereas withholding pre-operative RT was associated with a poorer prognosis. The present study supports that pre-operative RT was correctly introduced as a standard treatment before TME surgery in our national guideline. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	1710-1716
Number of pages	7
Journal	European Journal of Cancer
Volume	44
Issue number	12
DOIs	https://doi.org/10.1016/j.ejca.2008.05.004
Publication status	Published - 2008

Research programs

EMC NIHES-02-65-02

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejca.2008.05.004

http://hdl.handle.net/1765/29913

Cite this

den Dulk, M., Krijnen, P., Marijnen, CAM., Rutten, R., van de Poll-Franse, LV., Putter, H., Kranenbarg, EMK., Jansen-Landheer, MLEA., Coebergh, J. W., & van de Velde, CJH. (2008). Improved overall survival for patients with rectal cancer since 1990: The effects of TME surgery and pre-operative radiotherapy. European Journal of Cancer, 44(12), 1710-1716. https://doi.org/10.1016/j.ejca.2008.05.004

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title = "Improved overall survival for patients with rectal cancer since 1990: The effects of TME surgery and pre-operative radiotherapy",

abstract = "Aim: The aim was to study the effects of the introduction of TME surgery and pre-operative radiotherapy on overall survival (OS) by comparing patients treated in the period before (1990-1995), during (1996-1999) and after (2000-2002) the TME trial. Patients and methods: Patients diagnosed with rectal carcinoma in the region of Comprehensive Cancer Centres South and West were used (n = 3179). Results: Five-year OS was, respectively, 56%, 62% and 65% in the pre-trial, trial and post-trial periods (p < 0.001). Pre-operative RT was increasingly used over time and significantly related to OS in the post-trial period (p = 0.002), but not in the pre-trial and trial periods. Conclusions: Population-based OS improved markedly since the introduction of TME surgery. With standardised TME surgery, pre-operative RT improved OS, whereas withholding pre-operative RT was associated with a poorer prognosis. The present study supports that pre-operative RT was correctly introduced as a standard treatment before TME surgery in our national guideline. (C) 2008 Elsevier Ltd. All rights reserved.",

author = "{den Dulk}, M and Krijnen, {P (Pieta)} and CAM Marijnen and Riekie Rutten and {van de Poll-Franse}, LV and H Putter and EMK Kranenbarg and MLEA Jansen-Landheer and Coebergh, {Jan Willem} and {van de Velde}, CJH",

year = "2008",

doi = "10.1016/j.ejca.2008.05.004",

language = "Undefined/Unknown",

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den Dulk, M, Krijnen, P, Marijnen, CAM, Rutten, R, van de Poll-Franse, LV, Putter, H, Kranenbarg, EMK, Jansen-Landheer, MLEA, Coebergh, JW & van de Velde, CJH 2008, 'Improved overall survival for patients with rectal cancer since 1990: The effects of TME surgery and pre-operative radiotherapy', European Journal of Cancer, vol. 44, no. 12, pp. 1710-1716. https://doi.org/10.1016/j.ejca.2008.05.004

TY - JOUR

T1 - Improved overall survival for patients with rectal cancer since 1990: The effects of TME surgery and pre-operative radiotherapy

AU - den Dulk, M

AU - Krijnen, P (Pieta)

AU - Marijnen, CAM

AU - Rutten, Riekie

AU - van de Poll-Franse, LV

AU - Putter, H

AU - Kranenbarg, EMK

AU - Jansen-Landheer, MLEA

AU - Coebergh, Jan Willem

AU - van de Velde, CJH

PY - 2008

Y1 - 2008

N2 - Aim: The aim was to study the effects of the introduction of TME surgery and pre-operative radiotherapy on overall survival (OS) by comparing patients treated in the period before (1990-1995), during (1996-1999) and after (2000-2002) the TME trial. Patients and methods: Patients diagnosed with rectal carcinoma in the region of Comprehensive Cancer Centres South and West were used (n = 3179). Results: Five-year OS was, respectively, 56%, 62% and 65% in the pre-trial, trial and post-trial periods (p < 0.001). Pre-operative RT was increasingly used over time and significantly related to OS in the post-trial period (p = 0.002), but not in the pre-trial and trial periods. Conclusions: Population-based OS improved markedly since the introduction of TME surgery. With standardised TME surgery, pre-operative RT improved OS, whereas withholding pre-operative RT was associated with a poorer prognosis. The present study supports that pre-operative RT was correctly introduced as a standard treatment before TME surgery in our national guideline. (C) 2008 Elsevier Ltd. All rights reserved.

AB - Aim: The aim was to study the effects of the introduction of TME surgery and pre-operative radiotherapy on overall survival (OS) by comparing patients treated in the period before (1990-1995), during (1996-1999) and after (2000-2002) the TME trial. Patients and methods: Patients diagnosed with rectal carcinoma in the region of Comprehensive Cancer Centres South and West were used (n = 3179). Results: Five-year OS was, respectively, 56%, 62% and 65% in the pre-trial, trial and post-trial periods (p < 0.001). Pre-operative RT was increasingly used over time and significantly related to OS in the post-trial period (p = 0.002), but not in the pre-trial and trial periods. Conclusions: Population-based OS improved markedly since the introduction of TME surgery. With standardised TME surgery, pre-operative RT improved OS, whereas withholding pre-operative RT was associated with a poorer prognosis. The present study supports that pre-operative RT was correctly introduced as a standard treatment before TME surgery in our national guideline. (C) 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.ejca.2008.05.004

DO - 10.1016/j.ejca.2008.05.004

M3 - Article

C2 - 18573654

SN - 0959-8049

VL - 44

SP - 1710

EP - 1716

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 12

ER -