Improvement of the cytological diagnosis of malignant mesothelioma

T. H. Van Der Kwast*, M. Delahaye, M. Versnel, H. Hoogsteden

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)


In cytological smears of effusions the distinction of malignant mesothelioma cells from reactive mesothelial cells and adenocarcinoma cells often causes a diagnostic dilemma, as most currently used cytomorphological and cytochemical criteria lack sufficient specificity or sensitivity. On cytological smears we investigated the diagnostic value of: 1) the presence of collagen cores within clusters of exfoliated cells; and 2) the application of immunocytochemistry with a panel of four monoclonal antibodies. The results show that collagen cores in cytological smears are present in over 50% of cases of malignant mesothelioma, whilst their (rare) occurrence in adenocarcinomas was confined to breast and ovarian carcinomas. In addition, we found that epithelial membrane antigen (EMA) and OV632 positive cells were present in the majority of malignant mesotheliomas, whilst EMA and OV632 positive cells were not found in smears from reactive effusions. In particular, OV632 appears to be a unique marker, as it stains a minority of adenocarcinomas. Therefore, this antibody enables a positive identification of malignant mesothelioma.

Original languageEnglish
Pages (from-to)57-58
Number of pages2
JournalEuropean Respiratory Review
Issue number11
Publication statusPublished - 1993


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