IMRT FOR IMAGE-GUIDED SINGLE VOCAL CORD IRRADIATION

Sarah Osman, Eleftheria Astreinidou, HCJ de Boer, F Keskin-Cambay, Sebastiaan Breedveld, P Voet, Abrahim Al-Mamgani, Ben Heijmen, Peter Levendag

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Abstract

Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T la glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques. Methods and Materials: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk include Results: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose +/- standard deviation to the planning target volume was 67 +/- 1 Gy. The contralateral vocal cord dose was reduced from 66 +/- 1 Gy in the conventional plans to 39 +/- 8 Gy and 36 +/- 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk. Conclusions: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates. (C) 2012 Elsevier Inc.
Original languageUndefined/Unknown
Pages (from-to)989-997
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume82
Issue number2
DOIs
Publication statusPublished - 2012

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