In search of hidden Q-fever outbreaks: linking syndromic hospital clusters to infected goat farms

CC van der Wijngaard, F Dijkstra, W (Wilfred) van Pelt, L van Asten, M Kretzschmar, B Schimmer, Nico Nagelkerke, P Vellema, GA Donker, Marion Koopmans

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27 Citations (Scopus)

Abstract

Large Q-fever outbreaks were reported in The Netherlands from May 2007 to 2009, with dairy-goat farms as the putative source. Since Q-fever outbreaks at such farms were first reported in 2005, we explored whether there was evidence of human outbreaks before May 2007. Space-time scan statistics were used to look for clusters of lower-respiratory infections (LRIs), hepatitis, and/or endocarditis in hospitalizations, 2005-2007. We assessed whether these were plausibly caused by Q fever, using patients' age, discharge diagnoses, indications for other causes, and overlap with reported Q fever in goats/humans. For seven detected LRI clusters and one hepatitis cluster, we considered Q fever a plausible cause. One of these clusters reflected the recognized May 2007 outbreak. Real-time syndromic surveillance would have detected four of the other clusters in 2007, one in 2006 and two in 2005, which might have resulted in detection of Q-fever outbreaks up to 2 years earlier.
Original languageUndefined/Unknown
Pages (from-to)19-26
Number of pages8
JournalEpidemiology & Infection
Volume139
Issue number1
DOIs
Publication statusPublished - 2011

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