TY - GEN
T1 - In-stent neoatherosclerosis
T2 - Photonic Therapeutics and Diagnostics IX
AU - Karanasos, Antonios
AU - Witberg, Karen
AU - Ligthart, Jurgen
AU - Toutouzas, Konstantinos
AU - Daemen, Joost
AU - Van Soest, Gijs
AU - Gnanadesigan, Muthukaruppan
AU - Van Mieghem, Nicholas
AU - Zijlstra, Felix
AU - Regar, Evelyn
N1 - © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
PY - 2013/3/8
Y1 - 2013/3/8
N2 - Purpose: In-stent neoatherosclerosis has been recognised in pathologic specimens of bare metal stents (BMS), and recently in first generation drug eluting stents (1st-DES), as well. However, in vivo data are scarce. By optical coherence tomography, we investigated the incidence and morphological characteristics of neoatherosclerosis (NA) very late after BMS or 1st-DES implantation. Methods: From 1/1/2007 to 31/1/2012, 52 patients from two institutions underwent >24 months follow-up OCT assessment of a BMS or a 1st-DES. NA was characterized using criteria for native atherosclerosis. Results: BMS had longer follow-up interval but no differences in clinical presentation at follow-up. No significant differences were evident in the incidence of NA, neointimal rupture, lipid content, neovascularization or macrophage infiltration between BMS and 1st-DES. There was however a trend for lower fibrous cap thickness (FCT) and for higher calcification in BMS. 1st-DES with neoatherosclerosis had longer interval from implantation compared to 1st-DES with homogeneous coverage, but there was no difference for BMS with or without neoatherosclerosis. Conclusions: The incidence and morphological characteristics of NA are similar between 1st-DES and BMS of more prolonged follow-up. Our findings suggest a time-dependent pattern in the incidence of NA in 1st-DES with 2-11 years follow-up.
AB - Purpose: In-stent neoatherosclerosis has been recognised in pathologic specimens of bare metal stents (BMS), and recently in first generation drug eluting stents (1st-DES), as well. However, in vivo data are scarce. By optical coherence tomography, we investigated the incidence and morphological characteristics of neoatherosclerosis (NA) very late after BMS or 1st-DES implantation. Methods: From 1/1/2007 to 31/1/2012, 52 patients from two institutions underwent >24 months follow-up OCT assessment of a BMS or a 1st-DES. NA was characterized using criteria for native atherosclerosis. Results: BMS had longer follow-up interval but no differences in clinical presentation at follow-up. No significant differences were evident in the incidence of NA, neointimal rupture, lipid content, neovascularization or macrophage infiltration between BMS and 1st-DES. There was however a trend for lower fibrous cap thickness (FCT) and for higher calcification in BMS. 1st-DES with neoatherosclerosis had longer interval from implantation compared to 1st-DES with homogeneous coverage, but there was no difference for BMS with or without neoatherosclerosis. Conclusions: The incidence and morphological characteristics of NA are similar between 1st-DES and BMS of more prolonged follow-up. Our findings suggest a time-dependent pattern in the incidence of NA in 1st-DES with 2-11 years follow-up.
UR - http://www.scopus.com/inward/record.url?scp=84878212823&partnerID=8YFLogxK
U2 - 10.1117/12.2006341
DO - 10.1117/12.2006341
M3 - Conference proceeding
AN - SCOPUS:84878212823
SN - 9780819493347
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photonic Therapeutics and Diagnostics IX
Y2 - 2 February 2013 through 7 February 2013
ER -