In Vitro Assessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein

Rogier Bodewes, Tiny Mieras, J Wrammert, R Ahmed, PC Wilson, Ron Fouchier, Ab Osterhaus, Guus Rimmelzwaan

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30 Citations (Scopus)

Abstract

Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8(+) T cells by dendritic cells.
Original languageUndefined/Unknown
Pages (from-to)1333-1337
Number of pages5
JournalClinical and Vaccine Immunology
Volume20
Issue number8
DOIs
Publication statusPublished - 2013

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