Incidence and multivariable correlates of long-term mortality in patients treated with surgical or percutaneous revascularization in the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial

V Farooq, PWJC (Patrick) Serruys, Fatma Bektas, Pascal Vranckx, Roberto Diletti, HMG Garcia, DR Holmes, Arie-Pieter Kappetein, M Mack, T Feldman, MC Morice, A Colombo, Marie-Angele Morel, T (Ton) de Vries, Gerrit-anne Es, Ewout Steyerberg, KD Dawkins, FW Mohr, S James, E Stahle

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Abstract

Aims The aim of this investigation was to determine the incidence and multivariable correlates of long-term (4-year) mortality in patients treated with surgical or percutaneous revascularization in the synergy between percutaneous coronary intervention (PCI) with TAXUS Express and Cardiac Surgery (SYNTAX) trial. Methods and results A total of 1800 patients were randomized to undergo coronary artery bypass graft (CABG) surgery (n = 897) or PCI (n = 903). Prospectively collected baseline and peri-and post-procedural data were used to determine independent correlates of 4-year all-cause death in the CABG and the PCI arms (Cox proportional hazards model). Four-year mortality rates in the CABG and the PCI arms were 9.0% [74 deaths (12 in-hospital)] and 11.8% [104 deaths (16 in-hospital)], respectively (log-r Conclusion Independent correlates of 4-year mortality in the SYNTAX trial were multifactorial. Lack of discharge aspirin and lack of post-procedural anti-platelet therapy were the strongest independent correlates of mortality in the CABG and the PCI arms, respectively. Peripheral vascular disease is a common independent correlate of 4-year mortality and may be a marker of the severity of baseline coronary disease and risk of future native coronary disease (and extra-cardiac disease) progression.
Original languageUndefined/Unknown
Pages (from-to)3105-3113
Number of pages9
JournalEuropean Heart Journal
Volume33
Issue number24
DOIs
Publication statusPublished - 2012

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