Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study

Jasper M. Smit*, Lotte Exterkate, Arne J. Van Tienhoven, Mark E. Haaksma, Micah L.A. Heldeweg, Lucas Fleuren, Patrick Thoral, Tariq A. Dam, Leo M.A. Heunks, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert Jan Wils, Tim Frenzel, Alexander P. Vlaar, Dave A. Dongelmans, Remko De Jong, Marco Peters, Marlijn J.A. KampsDharmanand Ramnarain, Ralph Nowitzky, Fleur G.C.A. Nooteboom, Wouter De Ruijter, Louise C. Urlings-Strop, Ellen G.M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P.C. De Jager, Stefaan H.A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter Van Den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul De Jong, Thijs C.D. Rettig, Sesmu Arbous, Bas Vonk, Tomas Machado, Armand R.J. Girbes, Elske Sieswerda, Paul W.G. Elbers, Pieter R. Tuinman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

Original languageEnglish
Pages (from-to)358-365
Number of pages8
JournalShock
Volume58
Issue number5
DOIs
Publication statusPublished - 1 Nov 2022

Bibliographical note

Funding Information:
This work was supported by institutional funding only.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Fingerprint

Dive into the research topics of 'Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study'. Together they form a unique fingerprint.

Cite this