Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study

Jasper M. Smit; Lotte Exterkate; Arne J. Van Tienhoven; Mark E. Haaksma; Micah L.A. Heldeweg; Lucas Fleuren; Patrick Thoral; Tariq A. Dam; Leo M.A. Heunks; Diederik Gommers; Olaf L. Cremer; Rob J. Bosman; Sander Rigter; Evert Jan Wils; Tim Frenzel; Alexander P. Vlaar; Dave A. Dongelmans; Remko De Jong; Marco Peters; Marlijn J.A. Kamps; Dharmanand Ramnarain; Ralph Nowitzky; Fleur G.C.A. Nooteboom; Wouter De Ruijter; Louise C. Urlings-Strop; Ellen G.M. Smit; D. Jannet Mehagnoul-Schipper; Tom Dormans; Cornelis P.C. De Jager; Stefaan H.A. Hendriks; Sefanja Achterberg; Evelien Oostdijk; Auke C. Reidinga; Barbara Festen-Spanjer; Gert B. Brunnekreef; Alexander D. Cornet; Walter Van Den Tempel; Age D. Boelens; Peter Koetsier; Judith Lens; Harald J. Faber; A. Karakus; Robert Entjes; Paul De Jong; Thijs C.D. Rettig; Sesmu Arbous; Bas Vonk; Tomas Machado; Armand R.J. Girbes; Elske Sieswerda; Paul W.G. Elbers; Pieter R. Tuinman

doi:10.1097/shk.0000000000001994

Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study

Jasper M. Smit^*
, Lotte Exterkate
, Arne J. Van Tienhoven
, Mark E. Haaksma
, Micah L.A. Heldeweg
, Lucas Fleuren
, Patrick Thoral
, Tariq A. Dam
, Leo M.A. Heunks
, Diederik Gommers
, Olaf L. Cremer
, Rob J. Bosman
, Sander Rigter
, Evert Jan Wils
, Tim Frenzel
, Alexander P. Vlaar
, Dave A. Dongelmans
, Remko De Jong
, Marco Peters
, Marlijn J.A. Kamps

Dharmanand Ramnarain, Ralph Nowitzky, Fleur G.C.A. Nooteboom, Wouter De Ruijter, Louise C. Urlings-Strop, Ellen G.M. Smit, D. Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P.C. De Jager, Stefaan H.A. Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C. Reidinga, Barbara Festen-Spanjer, Gert B. Brunnekreef, Alexander D. Cornet, Walter Van Den Tempel, Age D. Boelens, Peter Koetsier, Judith Lens, Harald J. Faber, A. Karakus, Robert Entjes, Paul De Jong, Thijs C.D. Rettig, Sesmu Arbous, Bas Vonk, Tomas Machado, Armand R.J. Girbes, Elske Sieswerda, Paul W.G. Elbers, Pieter R. Tuinman

^*Corresponding author for this work

Intensive Care

Vrije Universiteit Amsterdam
Amsterdam Leiden Intensive care Focused Echography (A'dam)
Onze Lieve Vrouwe Gasthuis
Utrecht University
St. Antonius Ziekenhuis
Radboud University Medical Center
Amsterdam UMC
BovenIJ Hospital
Canisius Wilhelmina Hospital
Catharina Hospital
ETZ Elisabeth
Laurentius Hospital
Reinier de Graaf Groep
Spaarne Gasthuis
VieCuri Medisch Centrum
Zuyderland Medical Center (Heerlen)
Jeroen Bosch Ziekenhuis
Albert Schweitzer Ziekenhuis
Haaglanden Medisch Centrum
Maasstad Hospital
BWC
Gelderland Valley Hospital
Department of Intensive Care
Medisch Spectrum Twente
Ikazia Hospital
Medical Centre Leeuwarden
WZA
Diakonessenhuis Utrecht
Slingeland Ziekenhuis
Amphia Hospital
Leiden University Medical Centre
Pacmed
Franciscus Gasthuis & Vlietland
Haga Ziekenhuis
Northwest Clinics Alkmaar
IJsselland Ziekenhuis

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

4 Downloads (Pure)

Abstract

Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

Original language	English
Pages (from-to)	358-365
Number of pages	8
Journal	Shock
Volume	58
Issue number	5
DOIs	https://doi.org/10.1097/shk.0000000000001994
Publication status	Published - 1 Nov 2022

Bibliographical note

Funding Information:
This work was supported by institutional funding only.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

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10.1097/shk.0000000000001994

INCIDENCE, RISK FACTORS, AND OUTCOME OF SUSPECTED CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN CRITICALLY ILL COVID-19 PATIENTS A MULTICENTER RETROSPECTIVE COHORT STUDYFinal published version, 403 KBLicence: Article 25fa Dutch Copyright Act

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Smit, J. M., Exterkate, L., Van Tienhoven, A. J., Haaksma, M. E., Heldeweg, M. L. A., Fleuren, L., Thoral, P., Dam, T. A., Heunks, L. M. A., Gommers, D., Cremer, O. L., Bosman, R. J., Rigter, S., Wils, E. J., Frenzel, T., Vlaar, A. P., Dongelmans, D. A., De Jong, R., Peters, M., ... Tuinman, P. R. (2022). Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study. Shock, 58(5), 358-365. https://doi.org/10.1097/shk.0000000000001994

@article{238f9dc50ac54bc4a0ce0330951f08dc,

title = "Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study",

abstract = "Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9\% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95\% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95\% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.",

author = "Smit, \{Jasper M.\} and Lotte Exterkate and \{Van Tienhoven\}, \{Arne J.\} and Haaksma, \{Mark E.\} and Heldeweg, \{Micah L.A.\} and Lucas Fleuren and Patrick Thoral and Dam, \{Tariq A.\} and Heunks, \{Leo M.A.\} and Diederik Gommers and Cremer, \{Olaf L.\} and Bosman, \{Rob J.\} and Sander Rigter and Wils, \{Evert Jan\} and Tim Frenzel and Vlaar, \{Alexander P.\} and Dongelmans, \{Dave A.\} and \{De Jong\}, Remko and Marco Peters and Kamps, \{Marlijn J.A.\} and Dharmanand Ramnarain and Ralph Nowitzky and Nooteboom, \{Fleur G.C.A.\} and \{De Ruijter\}, Wouter and Urlings-Strop, \{Louise C.\} and Smit, \{Ellen G.M.\} and Mehagnoul-Schipper, \{D. Jannet\} and Tom Dormans and \{De Jager\}, \{Cornelis P.C.\} and Hendriks, \{Stefaan H.A.\} and Sefanja Achterberg and Evelien Oostdijk and Reidinga, \{Auke C.\} and Barbara Festen-Spanjer and Brunnekreef, \{Gert B.\} and Cornet, \{Alexander D.\} and \{Van Den Tempel\}, Walter and Boelens, \{Age D.\} and Peter Koetsier and Judith Lens and Faber, \{Harald J.\} and A. Karakus and Robert Entjes and \{De Jong\}, Paul and Rettig, \{Thijs C.D.\} and Sesmu Arbous and Bas Vonk and Tomas Machado and Girbes, \{Armand R.J.\} and Elske Sieswerda and Elbers, \{Paul W.G.\} and Tuinman, \{Pieter R.\}",

year = "2022",

month = nov,

day = "1",

doi = "10.1097/shk.0000000000001994",

language = "English",

volume = "58",

pages = "358--365",

journal = "Shock",

issn = "1073-2322",

publisher = "Lippincott Williams \& Wilkins",

number = "5",

}

Smit, JM, Exterkate, L, Van Tienhoven, AJ, Haaksma, ME, Heldeweg, MLA, Fleuren, L, Thoral, P, Dam, TA, Heunks, LMA, Gommers, D, Cremer, OL, Bosman, RJ, Rigter, S, Wils, EJ, Frenzel, T, Vlaar, AP, Dongelmans, DA, De Jong, R, Peters, M, Kamps, MJA, Ramnarain, D, Nowitzky, R, Nooteboom, FGCA, De Ruijter, W, Urlings-Strop, LC, Smit, EGM, Mehagnoul-Schipper, DJ, Dormans, T, De Jager, CPC, Hendriks, SHA, Achterberg, S, Oostdijk, E, Reidinga, AC, Festen-Spanjer, B, Brunnekreef, GB, Cornet, AD, Van Den Tempel, W, Boelens, AD, Koetsier, P, Lens, J, Faber, HJ, Karakus, A, Entjes, R, De Jong, P, Rettig, TCD, Arbous, S, Vonk, B, Machado, T, Girbes, ARJ, Sieswerda, E, Elbers, PWG & Tuinman, PR 2022, 'Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study', Shock, vol. 58, no. 5, pp. 358-365. https://doi.org/10.1097/shk.0000000000001994

TY - JOUR

T1 - Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient

T2 - A multicenter retrospective cohort study

AU - Smit, Jasper M.

AU - Exterkate, Lotte

AU - Van Tienhoven, Arne J.

AU - Haaksma, Mark E.

AU - Heldeweg, Micah L.A.

AU - Fleuren, Lucas

AU - Thoral, Patrick

AU - Dam, Tariq A.

AU - Heunks, Leo M.A.

AU - Gommers, Diederik

AU - Cremer, Olaf L.

AU - Bosman, Rob J.

AU - Rigter, Sander

AU - Wils, Evert Jan

AU - Frenzel, Tim

AU - Vlaar, Alexander P.

AU - Dongelmans, Dave A.

AU - De Jong, Remko

AU - Peters, Marco

AU - Kamps, Marlijn J.A.

AU - Ramnarain, Dharmanand

AU - Nowitzky, Ralph

AU - Nooteboom, Fleur G.C.A.

AU - De Ruijter, Wouter

AU - Urlings-Strop, Louise C.

AU - Smit, Ellen G.M.

AU - Mehagnoul-Schipper, D. Jannet

AU - Dormans, Tom

AU - De Jager, Cornelis P.C.

AU - Hendriks, Stefaan H.A.

AU - Achterberg, Sefanja

AU - Oostdijk, Evelien

AU - Reidinga, Auke C.

AU - Festen-Spanjer, Barbara

AU - Brunnekreef, Gert B.

AU - Cornet, Alexander D.

AU - Van Den Tempel, Walter

AU - Boelens, Age D.

AU - Koetsier, Peter

AU - Lens, Judith

AU - Faber, Harald J.

AU - Karakus, A.

AU - Entjes, Robert

AU - De Jong, Paul

AU - Rettig, Thijs C.D.

AU - Arbous, Sesmu

AU - Vonk, Bas

AU - Machado, Tomas

AU - Girbes, Armand R.J.

AU - Sieswerda, Elske

AU - Elbers, Paul W.G.

AU - Tuinman, Pieter R.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

AB - Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

UR - https://www.scopus.com/pages/publications/85143088327

U2 - 10.1097/shk.0000000000001994

DO - 10.1097/shk.0000000000001994

M3 - Article

C2 - 36155964

AN - SCOPUS:85143088327

SN - 1073-2322

VL - 58

SP - 358

EP - 365

JO - Shock

JF - Shock

IS - 5

ER -

Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill Covid-19 patient: A multicenter retrospective cohort study

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