Incidence, treatment, and case-fatality of non-traumatic subarachnoid haemorrhage in the Netherlands

Roelof Risselada, Laura Vries, Diederik Dippel, Fop Kooten, Aad van der Lugt, Wiro Niessen, Azadeh Firouzian, Bruno Stricker, MCJM Sturkenboom

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Background: Non-traumatic subarachnoid haemorrhage (SAH) is a devastating disorder and in the majority of cases it is caused by rupture of an intracranial aneurysm. No actual data are available on the incidence of non-traumatic SAH and aneursymal SAH (aSAH) in the Netherlands and little is known about treatment patterns of aSAH. Our purpose was therefore to assess the incidence, treatment patterns, and case-fatality of non-traumatic (a)SAH within the Dutch general population. Methods: Two population based data sources were used for this retrospective cohort study. One was the nationwide hospital discharge registry (National Medical Registration, LMR). Cases were patients hospitalized for SAH (ICD-9-code 430) in 2001-2005. The second source was the Integrated Primary Care Information (IPCI) database, a medical record database allowing for case validation. Cases were patients with validated non-traumatic (a)SAH in 1996-2006. Incidence, treatment, and case-fatality were assessed. Results: The incidence rate (IR) of non-traumatic SAH was 7.12 per 100,000 PY (95%CI: 6.94-7.31) and increased with age. The IR of aSAH was 3.78 (95%CI: 2.98-4.72). Women had a twofold increased risk of non-traumatic SAH; this difference appeared after the fourth decade. Non-traumatic SAH fatality was 30% (95%CI: 29-31%). Of aSAH patients 64% (95%CI: 53-74%) were treated with a clipping procedure, and 26% (95%CI: 17-37%) with coiling. Conclusion: Non-traumatic SAH is a rare disease with substantial case-fatality; rates in the Netherlands are similar to other countries. Case-fatality is also similar as well as age and sex patterns in incidence. (C) 2011 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)483-487
Number of pages5
JournalClinical Neurology & Neurosurgery
Issue number6
Publication statusPublished - 2011

Research programs

  • EMC COEUR-09
  • EMC NIHES-01-64-03
  • EMC NIHES-03-77-02

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