Incidental findings on coronary computed tomography in women with selected reproductive disorders

Kim van der Ham, Charissa van Zwol-Janssens, the CREW Consortium, Birgitta K. Velthuis, Maria P.H. Koster, Yvonne V. Louwers, Dustin Goei, Maurits S.H. Blomjous, Arie Franx, Bart C.J.M. Fauser, Eric Boersma, Joop S.E. Laven, Ricardo P.J. Budde*

*Corresponding author for this work

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Objective: To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45–55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE). Methods: A total of 486 middle-aged women with PCOS (n = 101), POI (n = 97) or a history of PE (n = 288) underwent a CCT as part of a prior prospective study. IFs were categorized by their significance (minor, moderate and major). Follow-up information was collected from patients’ records. To investigate the impact of different field of views (FOVs), a subset of scans was analyzed in full FOV and small FOV. Results: In 96/486 (19.8%) women, one or more IFs were detected, of which 54/486 (11.1%) were classified as moderate/major and 48/486 (9.9%) required follow-up. A moderate/major IF was detected in 16/101 (15.9%) women with PCOS, 13/97 (13.4%) women with POI and 25/288 (8.7%) women with a history of PE. In 78 women with an IF detected in the full FOV, the IF was still visible in 60 (76.9%) women in the small FOV. In the full FOV, 46 women required follow-up, but using the small FOV this was reduced to 30 women. Conclusion: Using CCT as a cardiovascular disease screening tool in women with selected reproductive disorders increases the probability of detecting IFs that can cause anxiety and may generate extra costs, but can also reveal clinically relevant findings. Using a small FOV centered around the heart resulted in a lower prevalence of IFs and required less follow-up.

Original languageEnglish
Article number96
JournalInsights into Imaging
Issue number1
Publication statusPublished - 4 Jun 2022

Bibliographical note

Funding Information:
The CREw-IMAGO study is funded by the Dutch Heart Foundation (Grant 2013T083). The Dutch Heart Foundation had no role in the collection, analysis, and interpretation of data, nor in the decision to submit the article for publication.

Publisher Copyright: © 2022, The Author(s).


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