Incorrectly analysing stratified and minimised trials may lead to wrongfully rejecting superiority of interventions

Reinier C. A. van Linschoten*, Rachel West, Desirée van Noord, Nikki van Leeuwen

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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Abstract

It is with great interest that we read the report of Yoshida et al on the effect of second-generation narrow band imaging compared to white light imaging on detecting early gastric cancer in high-risk patients. The trial was expertly designed with a large patient population and, although superiority of narrow band imaging could not be proven, has important implications for further research on this topic. However, a significant issue concerning the analyses attracted our interest and we would like to comment on it. [...]
Original languageEnglish
Pages (from-to)1038-1039
Number of pages2
JournalGut
Volume71
Issue number5
Early online date8 Apr 2022
DOIs
Publication statusPublished - 1 May 2022

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