NEW & NOTEWORTHY Term babies born by cesarean section have elevated airway liquid volumes, which predisposes them to respiratory distress. Treatments targeting molecular mechanisms to clear lung liquid are ineffective for term newborn respiratory distress. We showed that respiratory support with an end-expiratory pressure supports lung function in near-term rabbits with elevated airway liquid volumes at birth. This study provides further physiological understanding of lung function in newborns with elevated airway liquid volumes at risk of respiratory distress.
Bibliographical noteFunding Information:
The research was supported by the Department of Health, Australian Government, National Health and Medical Research Council (NHMRC) Program Grant APP113902 (to S.B.H.) and the Victorian Government’s Operational Infrastructure Support Program. K.L. and M.J.K. acknowledge travel funding provided by the International Synchrotron Access Program (ISAP) managed by the Australian Synchrotron and funded by the Australian Government (ISAP12909). E.V.M. was supported by a Monash University Bridging Postdoctoral Fellowship (BPF17-0066) and an NHMRC Peter Doherty Biomedical Early Career Fellowship (APP1138049). A.B.T.P. was the recipient of a Vidi grant, The Netherlands Organization for Health Research and Development (ZonMw), part of the Innovational Research Incentives Scheme Veni-Vidi-Vici (NWO-Vidi 91716428). M.T. was supported by an NHMRC Early Career Fellowship (APP1111134). S.B.H. was supported by an NHMRC Principal Research Fellowship (APP1058537). M.J.K. was supported by an Australian Research Council Australian Research Fellowship (FT160100454).
© 2021 American Physiological Society. All rights reserved.