Increased organ sparing using shape-based treatment plan optimization for intensity modulated radiation therapy of pancreatic adenocarcinoma

Steven Petit, BB Wu, M Kazhdan, Xander den Dekker, P Simari, R Kumar, R Taylor, JM Herman, T McNutt

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Purpose: To develop a model to assess the quality of an IMRT treatment plan using data of prior patients with pancreatic adenocarcinoma. Methods: The dose to an organ at risk (OAR) depends in large part on its orientation and distance to the planning target volume (PTV). A database of 33 previously treated patients with pancreatic cancer was queried to find patients with less favorable PTV-OAR configuration than a new case. The minimal achieved dose among the selected patients should also be achievable for the OAR of the new case. This way the achievable doses to the OARs of 25 randomly selected pancreas cancer patients were pred Results: The predicted doses were achieved within 1 and 2 Gy for more than 82% and 94% of the patients, respectively, and were a good approximation of the minimal achievable doses. The improvement after replanning was 1.4 Gy (range 0-4.6 Gy) and 1.7 Gy (range 0-6.3 Gy) for the mean dose to the liver and the kidneys, respectively, without compromising target coverage or increasing radiation dose to the bowel, cord or stomach. Conclusions: The model could accurately predict the achievable doses, leading to a considerable decrease in dose to the OARs and an increase in treatment planning efficiency. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 102 (2012) 38-44
Original languageUndefined/Unknown
Pages (from-to)38-44
Number of pages7
JournalRadiotherapy and Oncology
Issue number1
Publication statusPublished - 2012

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  • EMC MM-03-32-04

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