Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion

Xiaopei Guo; Marco W.J. Schreurs; Fleur E. Marijnissen; Michiel C. Mommersteeg; Stella A.V. Nieuwenburg; Michail Doukas; Nicole S. Erler; Lisette G. Capelle; Marco J. Bruno; Maikel P. Peppelenbosch; Manon C.W. Spaander; the Proregal study group; Gwenny M. Fuhler

doi:10.3390/jcm12196152

Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion

Xiaopei Guo
, Marco W.J. Schreurs
, Fleur E. Marijnissen
, Michiel C. Mommersteeg
, Stella A.V. Nieuwenburg
, Michail Doukas
, Nicole S. Erler
, Lisette G. Capelle
, Marco J. Bruno
, Maikel P. Peppelenbosch
, Manon C.W. Spaander
, the Proregal study group
, Gwenny M. Fuhler^*

^*Corresponding author for this work

Erasmus University Medical Centre
Erasmus University Rotterdam
Meander Medical Center

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

95 Downloads (Pure)

Abstract

Background:

Autoimmune gastritis (AIG), characterized with the presence of anti-parietal-cell antibodies (APCA), is a risk factor for gastric cancer. However, AIG may go underdiagnosed, especially in the case of H. pylori infection and the presence of gastric precancerous lesions (GPL), due to the ambiguous pathology and delayed symptom onset.

Aim:

Investigate the prevalence and characteristics of AIG in GPL patients.

Methods:

Prevalence of AIG was determined with the presence of APCA in patients with GPL (n = 256) and the control group (n = 70). Pathological characteristics and levels of gastrin 17 (G17), pepsinogen (PG) I and II and anti-Helicobacter pylori IgG were assessed in GPL cases, and the severity of intestinal metaplasia and gastric atrophy was scored by expert pathologists.

Results:

APCA positivity was observed in 18% of cases vs. 7% of controls (p = 0.033). Only 3/256 patients were previously diagnosed with AIG. The presence of APCA was associated with corpus-limited and extended GPL. A receiver operating curve analysis demonstrated that the G17 and PGI/II ratio could identify APCA-positive patients within GPL cases (AUC: 0.884).

Conclusions:

The prevalence of AIG is higher in patients with GPL but goes undiagnosed. Using G17 and PG I/II as diagnostic markers can help to identify patients with AIG and improve surveillance programs for patients with GPL.

Original language	English
Article number	6152
Number of pages	12
Journal	Journal of Clinical Medicine
Volume	12
Issue number	19
DOIs	https://doi.org/10.3390/jcm12196152
Publication status	Published - 23 Sept 2023

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous LesionFinal published version, 621 KBLicence: CC BY

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Guo, X., Schreurs, M. W. J., Marijnissen, F. E., Mommersteeg, M. C., Nieuwenburg, S. A. V., Doukas, M., Erler, N. S., Capelle, L. G., Bruno, M. J., Peppelenbosch, M. P., Spaander, M. C. W., the Proregal study group, & Fuhler, G. M. (2023). Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion. Journal of Clinical Medicine, 12(19), Article 6152. https://doi.org/10.3390/jcm12196152

@article{69b124c724ed4a0f825ed7824337e1e0,

title = "Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion",

abstract = "Background: Autoimmune gastritis (AIG), characterized with the presence of anti-parietal-cell antibodies (APCA), is a risk factor for gastric cancer. However, AIG may go underdiagnosed, especially in the case of H. pylori infection and the presence of gastric precancerous lesions (GPL), due to the ambiguous pathology and delayed symptom onset. Aim: Investigate the prevalence and characteristics of AIG in GPL patients. Methods:Prevalence of AIG was determined with the presence of APCA in patients with GPL (n = 256) and the control group (n = 70). Pathological characteristics and levels of gastrin 17 (G17), pepsinogen (PG) I and II and anti-Helicobacter pylori IgG were assessed in GPL cases, and the severity of intestinal metaplasia and gastric atrophy was scored by expert pathologists. Results: APCA positivity was observed in 18\% of cases vs. 7\% of controls (p = 0.033). Only 3/256 patients were previously diagnosed with AIG. The presence of APCA was associated with corpus-limited and extended GPL. A receiver operating curve analysis demonstrated that the G17 and PGI/II ratio could identify APCA-positive patients within GPL cases (AUC: 0.884). Conclusions: The prevalence of AIG is higher in patients with GPL but goes undiagnosed. Using G17 and PG I/II as diagnostic markers can help to identify patients with AIG and improve surveillance programs for patients with GPL.",

author = "Xiaopei Guo and Schreurs, \{Marco W.J.\} and Marijnissen, \{Fleur E.\} and Mommersteeg, \{Michiel C.\} and Nieuwenburg, \{Stella A.V.\} and Michail Doukas and Erler, \{Nicole S.\} and Capelle, \{Lisette G.\} and Bruno, \{Marco J.\} and Peppelenbosch, \{Maikel P.\} and Spaander, \{Manon C.W.\} and \{the Proregal study group\} and Fuhler, \{Gwenny M.\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = sep,

day = "23",

doi = "10.3390/jcm12196152",

language = "English",

volume = "12",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "19",

}

Guo, X, Schreurs, MWJ, Marijnissen, FE, Mommersteeg, MC, Nieuwenburg, SAV , Doukas, M, Erler, NS, Capelle, LG, Bruno, MJ , Peppelenbosch, MP , Spaander, MCW, the Proregal study group & Fuhler, GM 2023, 'Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion', Journal of Clinical Medicine, vol. 12, no. 19, 6152. https://doi.org/10.3390/jcm12196152

TY - JOUR

T1 - Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion

AU - Guo, Xiaopei

AU - Schreurs, Marco W.J.

AU - Marijnissen, Fleur E.

AU - Mommersteeg, Michiel C.

AU - Nieuwenburg, Stella A.V.

AU - Doukas, Michail

AU - Erler, Nicole S.

AU - Capelle, Lisette G.

AU - Bruno, Marco J.

AU - Peppelenbosch, Maikel P.

AU - Spaander, Manon C.W.

AU - the Proregal study group

AU - Fuhler, Gwenny M.

PY - 2023/9/23

Y1 - 2023/9/23

N2 - Background: Autoimmune gastritis (AIG), characterized with the presence of anti-parietal-cell antibodies (APCA), is a risk factor for gastric cancer. However, AIG may go underdiagnosed, especially in the case of H. pylori infection and the presence of gastric precancerous lesions (GPL), due to the ambiguous pathology and delayed symptom onset. Aim: Investigate the prevalence and characteristics of AIG in GPL patients. Methods:Prevalence of AIG was determined with the presence of APCA in patients with GPL (n = 256) and the control group (n = 70). Pathological characteristics and levels of gastrin 17 (G17), pepsinogen (PG) I and II and anti-Helicobacter pylori IgG were assessed in GPL cases, and the severity of intestinal metaplasia and gastric atrophy was scored by expert pathologists. Results: APCA positivity was observed in 18% of cases vs. 7% of controls (p = 0.033). Only 3/256 patients were previously diagnosed with AIG. The presence of APCA was associated with corpus-limited and extended GPL. A receiver operating curve analysis demonstrated that the G17 and PGI/II ratio could identify APCA-positive patients within GPL cases (AUC: 0.884). Conclusions: The prevalence of AIG is higher in patients with GPL but goes undiagnosed. Using G17 and PG I/II as diagnostic markers can help to identify patients with AIG and improve surveillance programs for patients with GPL.

AB - Background: Autoimmune gastritis (AIG), characterized with the presence of anti-parietal-cell antibodies (APCA), is a risk factor for gastric cancer. However, AIG may go underdiagnosed, especially in the case of H. pylori infection and the presence of gastric precancerous lesions (GPL), due to the ambiguous pathology and delayed symptom onset. Aim: Investigate the prevalence and characteristics of AIG in GPL patients. Methods:Prevalence of AIG was determined with the presence of APCA in patients with GPL (n = 256) and the control group (n = 70). Pathological characteristics and levels of gastrin 17 (G17), pepsinogen (PG) I and II and anti-Helicobacter pylori IgG were assessed in GPL cases, and the severity of intestinal metaplasia and gastric atrophy was scored by expert pathologists. Results: APCA positivity was observed in 18% of cases vs. 7% of controls (p = 0.033). Only 3/256 patients were previously diagnosed with AIG. The presence of APCA was associated with corpus-limited and extended GPL. A receiver operating curve analysis demonstrated that the G17 and PGI/II ratio could identify APCA-positive patients within GPL cases (AUC: 0.884). Conclusions: The prevalence of AIG is higher in patients with GPL but goes undiagnosed. Using G17 and PG I/II as diagnostic markers can help to identify patients with AIG and improve surveillance programs for patients with GPL.

UR - https://www.scopus.com/pages/publications/85174217058

U2 - 10.3390/jcm12196152

DO - 10.3390/jcm12196152

M3 - Article

C2 - 37834796

AN - SCOPUS:85174217058

SN - 2077-0383

VL - 12

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 19

M1 - 6152

ER -

Increased Prevalence of Autoimmune Gastritis in Patients with a Gastric Precancerous Lesion

Abstract

Bibliographical note

UN SDGs

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