Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients

HG Raterman, AE Voskuyl, S Simsek, Marco Schreurs, IMW van Hoogstraten, MJL Peters, VP van Halm, BAC Dijkmans, P Lips, WF Lems, MT Nurmohamed

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


Objective: Autoimmune diseases such as rheumatoid arthritis (RA) and hypothyroidism tend to cluster, and this coexistence amplifies the elevated cardiovascular risk in RA. Whether thyroid peroxidase antibodies (TPOabs) are associated with increased cardiovascular disease (CVD) risk has not been studied extensively. Therefore, this study determined firstly the prevalence of TPOabs in RA and secondly whether TPOabs were associated with CVD. Moreover, this study explored whether TPOabs were related to RA characteristics. Design and methods: Data from the CARRE Study, an ongoing study investigating CVDs and its risk factors in RA (n=322), was used to ascertain the prevalence of TPOabs in RA patients. In addition, cardiovascular and RA disease characteristics were compared between TPOabs-positive and -negative patients at baseline and at a second visit after 3 years. Results: TPOabs were present in 47/322 (15%) RA patients and TSH levels were higher in TPOabs-positive patients (1.40 mU/l) compared with TPOabs-negative patients (1.26 mU/l, P=0.048). At baseline and after 3 years no association was observed between TPOabs and (risk factors for) CVD. Regression analyses revealed a significantly larger progression of carotid intima media thickness (cIMT; beta=0.13 mm) in TPOabs-positive compared with TPOabs-negative patients independent of risk factors for cIMT Conclusions: TPOabs were associated with increased cIMT progression. Moreover, an association between TPOabs and DAS28 was observed. Hence, TPOabs seems to have a role in the amplified cardiovascular risk in RA patients.
Original languageUndefined/Unknown
Pages (from-to)751-757
Number of pages7
JournalEuropean Journal of Endocrinology
Issue number6
Publication statusPublished - 2013

Research programs

  • EMC MM-02-72-02

Cite this