Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Janneke Wilschut, Dik Habbema, SD Ramsey, Rob Boer, Caspar Looman, Marjolein Ballegooijen

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

Objective It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without. Methods We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder. Results Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4-3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05-1.07). The age trend did not differ significantly between the two groups. Conclusion Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.
Original languageUndefined/Unknown
Pages (from-to)2287-2293
Number of pages7
JournalCancer Causes & Control
Volume21
Issue number12
DOIs
Publication statusPublished - 2010

Cite this