Individualizing treatment in Von Willebrand disease: One size does not fit all

The focus of this thesis was on individualizing dosing of treatment in von Willebrand disease (VWD), the most common inherited bleeding disorder. First, current treatment strategies were evaluated and reviewed to identify where improvements can be made. Secondly, several population pharmacokinetic (PK) models were developed, which can be applied for individualized PK-guided dosing of the currently available treatment. Thirdly, a study protocol on implementation of PK-guided dosing of desmopressin and VWF-containing concentrates in clinical practice was presented, as well as new covariates that can be useful for further research.