Inflammaging and Blood Pressure Profiles in Late Life: The Screening for CKD among Older People across Europe (SCOPE) Study

Lisanne Tap*, Andrea Corsonello, on behalf of the SCOPE Investigators, Mirko Di Rosa, Paolo Fabbietti, Francesc Formiga, Rafael Moreno-González, Johan Ärnlöv, Axel C. Carlsson, Harmke A. Polinder-Bos, Regina E. Roller-Wirnsberger, Gerhard H. Wirnsberger, Tomasz Kostka, Agnieszka Guligowska, Rada Artzi-Medvedik, Ilan Yehoshua, Christian Weingart, Cornel C. Sieber, Pedro Gil, Sara Lainez MartinezFabrizia Lattanzio, Francesco U.S. Mattace-Raso

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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The neutrophil-to-lymphocyte ratio (NLR) is a marker for systemic inflammation. Since inflammation plays a relevant role in vascular aging, the aim of this study was to investigate whether NLR is associated with blood pressure profiles in older adults. This study was performed within the framework of the SCOPE study including 2461 outpatients aged 75 years and over. Mean blood pressure values, namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were investigated across tertiles of NLR. Change in blood pressure levels in 2 years of follow-up were compared across categories of baseline NLR. Data of 2397 individuals were used, of which 1854 individuals had hypertension. Mean values of blood pressure did not differ across categories of baseline NLR in individuals without hypertension. Individuals with hypertension with a high-range NLR had lower SBP and PP when compared to those in low-range NLR (mean difference SBP −2.94 mmHg, p = 0.032 and PP −2.55 mmHg, p = 0.030). Mean change in blood pressure in 2 years did only slightly differ in non-clinically relevant ranges, when compared across tertiles of baseline NLR. NLR as a marker of inflammaging was not associated with unfavorable blood pressure profiles in older individuals with or without hypertension.

Original languageEnglish
Article number7311
JournalJournal of Clinical Medicine
Issue number24
Publication statusPublished - 9 Dec 2022

Bibliographical note

Funding Information:
The SCOPE project was granted by the European Union Horizon 2020 program, under the Grant Agreement n°634869.

Publisher Copyright:
© 2022 by the authors.


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