Influence of plaque composition on mechanisms of percutaneous transluminal coronary balloon angioplasty assessed by ultrasound imaging

Robert Gil; Carlo Di Mario; Francesco Prati; Clemens Von Birgelen; Peter Ruygrok; Jos R.T.C. Roelandt; Patrick W. Serruys; W. M. Van Swijndregt; J. Ligthart

doi:10.1016/S0002-8703(96)90541-4

Influence of plaque composition on mechanisms of percutaneous transluminal coronary balloon angioplasty assessed by ultrasound imaging

Robert Gil, Carlo Di Mario, Francesco Prati, Clemens Von Birgelen, Peter Ruygrok, Jos R.T.C. Roelandt, Patrick W. Serruys^*, W. M. Van Swijndregt, J. Ligthart

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In this study the influence of plaque composition on mechanism of immediate lumen enlargement after PTCA were assessed by serial ultrasound imaging in 77 patients. According to the preprocedural ultrasonic plaque characteristics, the lesions were classified as soft (54.5%), diffusely calcified (14.3%), and mixed (31.2%). The total arc of calcium and plaque eccentricity were also calculated. The mean balloon/artery ratio was equal for all types of lesions (1.07 ± 0.19), but diffusely calcified lesions required a higher maximal balloon inflation pressure (11.3 ± 3.75 atm vs 9.0 ± 3.15 atm for calcified and soft lesions, respectively, p < 0.05). The increase in lumen area after PTCA was similar in soft and mixed lesions (3.49 ± 1.61 mm² vs 3.56 ± 1.58 mm², NS) and was slightly lower in diffusely calcified lesions (2.97 ± 1.33 mm², NS). Reduction in plaque area was the main operative mechanism in lesions with soft plaque, explaining 77.9% of the acute lumen gain. Expansion of the total vessel area was the predominant mechanism of lumen area increase in lesions with calcified and mixed plaques (99.1% vs 74.2%, respectively, NS). In particular, lesions with a total arc of calcium >90 degrees showed a high prevalence of vessel expansion as a mechanism of lumen enlargement compared with lesions with a calcium arc <90° (79.3% vs 23.8%, respectively, p < 0.05). In the studied group, presence of calcification was highly associated with wall fracture and dissection after balloon dilatation (93.4% vs 6.6% in lesions with and without calcifications, respectively, p < 0.05). A trend toward a greater degree of plaque reduction in concentric lesions in comparison to eccentric lesions was observed (58.3% vs 48.5%, respectively, NS). In conclusion, immediate lumen enlargement after PTCA does not differ for soft and mixed plaques. Diffusely calcific plaques show a smaller lumen enlargement despite a higher balloon inflation pressure. Plaque compression or axial redistribution is the main operative mechanism of PTCA in soft plaques, whereas an increase in total vessel area determines the lumen enlargement in mixed/calcific plaques. Plaque fracture or wall dissection is almost invariably associated with presence of plaque calcification.

Original language	English
Pages (from-to)	591-597
Number of pages	7
Journal	American Heart Journal
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/S0002-8703(96)90541-4
Publication status	Published - 1996

Bibliographical note

Funding Information:
From the Intracoronary Imaging Laboratory and Cardiac Catheterization Laboratory, Thoraxcenter. Dr. Gil is the recipient of the European Society of Cardiology Training Fellowship, 1994 (Sophia Antipolis-Niee). Dr. van Birgelen is the recipient of a Fellowship of the German Research Society (Deutsche Forschungs Gemeinschaft, Bonn). Received for publication April 26, 1995; accepted June 8, 1995. Reprint requests: Patrick Serruys, MD, PhD, Cardiac Catheterization Laboratory, Division of Cardiology, Thoraxcentre, BD 376, Erasmus University, P.O. Box 1738, 3015 GD Rotterdam, The Netherlands. AM HEARTJ 1996;131:591-7. Cepyright © 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + 0 4/1/69491

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Gil, R., Di Mario, C., Prati, F., Von Birgelen, C., Ruygrok, P., Roelandt, J. R. T. C., Serruys, P. W., Van Swijndregt, W. M., & Ligthart, J. (1996). Influence of plaque composition on mechanisms of percutaneous transluminal coronary balloon angioplasty assessed by ultrasound imaging. American Heart Journal, 131(3), 591-597. https://doi.org/10.1016/S0002-8703(96)90541-4

@article{15634bc97d474046b2c11aac78d96a7e,

title = "Influence of plaque composition on mechanisms of percutaneous transluminal coronary balloon angioplasty assessed by ultrasound imaging",

abstract = "In this study the influence of plaque composition on mechanism of immediate lumen enlargement after PTCA were assessed by serial ultrasound imaging in 77 patients. According to the preprocedural ultrasonic plaque characteristics, the lesions were classified as soft (54.5%), diffusely calcified (14.3%), and mixed (31.2%). The total arc of calcium and plaque eccentricity were also calculated. The mean balloon/artery ratio was equal for all types of lesions (1.07 ± 0.19), but diffusely calcified lesions required a higher maximal balloon inflation pressure (11.3 ± 3.75 atm vs 9.0 ± 3.15 atm for calcified and soft lesions, respectively, p < 0.05). The increase in lumen area after PTCA was similar in soft and mixed lesions (3.49 ± 1.61 mm2 vs 3.56 ± 1.58 mm2, NS) and was slightly lower in diffusely calcified lesions (2.97 ± 1.33 mm2, NS). Reduction in plaque area was the main operative mechanism in lesions with soft plaque, explaining 77.9% of the acute lumen gain. Expansion of the total vessel area was the predominant mechanism of lumen area increase in lesions with calcified and mixed plaques (99.1% vs 74.2%, respectively, NS). In particular, lesions with a total arc of calcium >90 degrees showed a high prevalence of vessel expansion as a mechanism of lumen enlargement compared with lesions with a calcium arc <90° (79.3% vs 23.8%, respectively, p < 0.05). In the studied group, presence of calcification was highly associated with wall fracture and dissection after balloon dilatation (93.4% vs 6.6% in lesions with and without calcifications, respectively, p < 0.05). A trend toward a greater degree of plaque reduction in concentric lesions in comparison to eccentric lesions was observed (58.3% vs 48.5%, respectively, NS). In conclusion, immediate lumen enlargement after PTCA does not differ for soft and mixed plaques. Diffusely calcific plaques show a smaller lumen enlargement despite a higher balloon inflation pressure. Plaque compression or axial redistribution is the main operative mechanism of PTCA in soft plaques, whereas an increase in total vessel area determines the lumen enlargement in mixed/calcific plaques. Plaque fracture or wall dissection is almost invariably associated with presence of plaque calcification.",

author = "Robert Gil and {Di Mario}, Carlo and Francesco Prati and {Von Birgelen}, Clemens and Peter Ruygrok and Roelandt, {Jos R.T.C.} and Serruys, {Patrick W.} and {Van Swijndregt}, {W. M.} and J. Ligthart",

note = "Funding Information: From the Intracoronary Imaging Laboratory and Cardiac Catheterization Laboratory, Thoraxcenter. Dr. Gil is the recipient of the European Society of Cardiology Training Fellowship, 1994 (Sophia Antipolis-Niee). Dr. van Birgelen is the recipient of a Fellowship of the German Research Society (Deutsche Forschungs Gemeinschaft, Bonn). Received for publication April 26, 1995; accepted June 8, 1995. Reprint requests: Patrick Serruys, MD, PhD, Cardiac Catheterization Laboratory, Division of Cardiology, Thoraxcentre, BD 376, Erasmus University, P.O. Box 1738, 3015 GD Rotterdam, The Netherlands. AM HEARTJ 1996;131:591-7. Cepyright {\textcopyright} 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + 0 4/1/69491",

year = "1996",

doi = "10.1016/S0002-8703(96)90541-4",

language = "English",

volume = "131",

pages = "591--597",

journal = "American Heart Journal",

issn = "0002-8703",

publisher = "Elsevier Inc.",

number = "3",

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TY - JOUR

T1 - Influence of plaque composition on mechanisms of percutaneous transluminal coronary balloon angioplasty assessed by ultrasound imaging

AU - Gil, Robert

AU - Di Mario, Carlo

AU - Prati, Francesco

AU - Von Birgelen, Clemens

AU - Ruygrok, Peter

AU - Roelandt, Jos R.T.C.

AU - Serruys, Patrick W.

AU - Van Swijndregt, W. M.

AU - Ligthart, J.

N1 - Funding Information: From the Intracoronary Imaging Laboratory and Cardiac Catheterization Laboratory, Thoraxcenter. Dr. Gil is the recipient of the European Society of Cardiology Training Fellowship, 1994 (Sophia Antipolis-Niee). Dr. van Birgelen is the recipient of a Fellowship of the German Research Society (Deutsche Forschungs Gemeinschaft, Bonn). Received for publication April 26, 1995; accepted June 8, 1995. Reprint requests: Patrick Serruys, MD, PhD, Cardiac Catheterization Laboratory, Division of Cardiology, Thoraxcentre, BD 376, Erasmus University, P.O. Box 1738, 3015 GD Rotterdam, The Netherlands. AM HEARTJ 1996;131:591-7. Cepyright © 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + 0 4/1/69491

PY - 1996

Y1 - 1996

N2 - In this study the influence of plaque composition on mechanism of immediate lumen enlargement after PTCA were assessed by serial ultrasound imaging in 77 patients. According to the preprocedural ultrasonic plaque characteristics, the lesions were classified as soft (54.5%), diffusely calcified (14.3%), and mixed (31.2%). The total arc of calcium and plaque eccentricity were also calculated. The mean balloon/artery ratio was equal for all types of lesions (1.07 ± 0.19), but diffusely calcified lesions required a higher maximal balloon inflation pressure (11.3 ± 3.75 atm vs 9.0 ± 3.15 atm for calcified and soft lesions, respectively, p < 0.05). The increase in lumen area after PTCA was similar in soft and mixed lesions (3.49 ± 1.61 mm2 vs 3.56 ± 1.58 mm2, NS) and was slightly lower in diffusely calcified lesions (2.97 ± 1.33 mm2, NS). Reduction in plaque area was the main operative mechanism in lesions with soft plaque, explaining 77.9% of the acute lumen gain. Expansion of the total vessel area was the predominant mechanism of lumen area increase in lesions with calcified and mixed plaques (99.1% vs 74.2%, respectively, NS). In particular, lesions with a total arc of calcium >90 degrees showed a high prevalence of vessel expansion as a mechanism of lumen enlargement compared with lesions with a calcium arc <90° (79.3% vs 23.8%, respectively, p < 0.05). In the studied group, presence of calcification was highly associated with wall fracture and dissection after balloon dilatation (93.4% vs 6.6% in lesions with and without calcifications, respectively, p < 0.05). A trend toward a greater degree of plaque reduction in concentric lesions in comparison to eccentric lesions was observed (58.3% vs 48.5%, respectively, NS). In conclusion, immediate lumen enlargement after PTCA does not differ for soft and mixed plaques. Diffusely calcific plaques show a smaller lumen enlargement despite a higher balloon inflation pressure. Plaque compression or axial redistribution is the main operative mechanism of PTCA in soft plaques, whereas an increase in total vessel area determines the lumen enlargement in mixed/calcific plaques. Plaque fracture or wall dissection is almost invariably associated with presence of plaque calcification.

AB - In this study the influence of plaque composition on mechanism of immediate lumen enlargement after PTCA were assessed by serial ultrasound imaging in 77 patients. According to the preprocedural ultrasonic plaque characteristics, the lesions were classified as soft (54.5%), diffusely calcified (14.3%), and mixed (31.2%). The total arc of calcium and plaque eccentricity were also calculated. The mean balloon/artery ratio was equal for all types of lesions (1.07 ± 0.19), but diffusely calcified lesions required a higher maximal balloon inflation pressure (11.3 ± 3.75 atm vs 9.0 ± 3.15 atm for calcified and soft lesions, respectively, p < 0.05). The increase in lumen area after PTCA was similar in soft and mixed lesions (3.49 ± 1.61 mm2 vs 3.56 ± 1.58 mm2, NS) and was slightly lower in diffusely calcified lesions (2.97 ± 1.33 mm2, NS). Reduction in plaque area was the main operative mechanism in lesions with soft plaque, explaining 77.9% of the acute lumen gain. Expansion of the total vessel area was the predominant mechanism of lumen area increase in lesions with calcified and mixed plaques (99.1% vs 74.2%, respectively, NS). In particular, lesions with a total arc of calcium >90 degrees showed a high prevalence of vessel expansion as a mechanism of lumen enlargement compared with lesions with a calcium arc <90° (79.3% vs 23.8%, respectively, p < 0.05). In the studied group, presence of calcification was highly associated with wall fracture and dissection after balloon dilatation (93.4% vs 6.6% in lesions with and without calcifications, respectively, p < 0.05). A trend toward a greater degree of plaque reduction in concentric lesions in comparison to eccentric lesions was observed (58.3% vs 48.5%, respectively, NS). In conclusion, immediate lumen enlargement after PTCA does not differ for soft and mixed plaques. Diffusely calcific plaques show a smaller lumen enlargement despite a higher balloon inflation pressure. Plaque compression or axial redistribution is the main operative mechanism of PTCA in soft plaques, whereas an increase in total vessel area determines the lumen enlargement in mixed/calcific plaques. Plaque fracture or wall dissection is almost invariably associated with presence of plaque calcification.

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DO - 10.1016/S0002-8703(96)90541-4

M3 - Article

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VL - 131

SP - 591

EP - 597

JO - American Heart Journal

JF - American Heart Journal

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ER -

Influence of plaque composition on mechanisms of percutaneous transluminal coronary balloon angioplasty assessed by ultrasound imaging

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