Influenza B viruses: not to be discounted

Carolien Sandt, Rogier Bodewes, Guus Rimmelzwaan, Rory de Vries

Research output: Contribution to journalArticleAcademicpeer-review

80 Citations (Scopus)

Abstract

In contrast to influenza A viruses, which have been investigated extensively, influenza B viruses have attracted relatively little attention. However, influenza B viruses are an important cause of morbidity and mortality in the human population and full understanding of their biological and epidemiological properties is imperative to better control this important pathogen. However, some of its characteristics are still elusive and warrant investigation. Here, we review evolution, epidemiology, pathogenesis and immunity and identify gaps in our knowledge of influenza B viruses. The divergence of two antigenically distinct influenza B viruses is highlighted. The co-circulation of viruses of these two lineages necessitated the development of quadrivalent influenza vaccines, which is discussed in addition to possibilities to develop universal vaccination strategies.
Original languageUndefined/Unknown
Pages (from-to)1447-1465
Number of pages19
JournalFuture Microbiology
Volume10
Issue number9
DOIs
Publication statusPublished - 2015

Research programs

  • EMC MM-04-27-01

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