INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

TF Meehan; CK Chen; G Koscielny; M Relac; P Wilkinson; P Flicek; H Parkinson; A Castro; S Fessele; R Steinkamp; M Hagn; M Raess; MH de Angelis; J Bottomley; R Ramirez-Solis; D Smedley; S Ball; A Blake; M Fray; J Kenyon; AM Mallon; S Brown; M Massimi; R Matteoni; G Tocchini-Valentini; Y Herault; G Kollias; B Ulfhake; J Demengeot; C Fremond; F Bosch; L Montoliu; R Soininen; K Schughart; C Brakebusch; R Sedlacek; T Rulicke; C McKerlie; B Malissen; F Iraqi; J Jonkers; H Russig; Danny Huylebroeck

doi:10.1093/nar/gku1193

INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

TF Meehan
, CK Chen
, G Koscielny
, M Relac
, P Wilkinson
, P Flicek
, H Parkinson
, A Castro
, S Fessele
, R Steinkamp
, M Hagn
, M Raess
, MH de Angelis
, J Bottomley
, R Ramirez-Solis
, D Smedley
, S Ball
, A Blake
, M Fray
, J Kenyon

AM Mallon, S Brown, M Massimi, R Matteoni, G Tocchini-Valentini, Y Herault, G Kollias, B Ulfhake, J Demengeot, C Fremond, F Bosch, L Montoliu, R Soininen, K Schughart, C Brakebusch, R Sedlacek, T Rulicke, C McKerlie, B Malissen, F Iraqi, J Jonkers, H Russig, Danny Huylebroeck

Cell biology

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.

Original language	Undefined/Unknown
Pages (from-to)	D1171-D1175
Journal	Nucleic Acids Research
Volume	43
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gku1193
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research programs

EMC MGC-02-13-02

Access to Document

10.1093/nar/gku1193

Cite this

Meehan, TF., Chen, CK., Koscielny, G., Relac, M., Wilkinson, P., Flicek, P., Parkinson, H., Castro, A., Fessele, S., Steinkamp, R., Hagn, M., Raess, M., de Angelis, MH., Bottomley, J., Ramirez-Solis, R., Smedley, D., Ball, S., Blake, A., Fray, M., ... Huylebroeck, D. (2015). INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Research, 43(D1), D1171-D1175. https://doi.org/10.1093/nar/gku1193

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title = "INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community",

abstract = "The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.",

author = "TF Meehan and CK Chen and G Koscielny and M Relac and P Wilkinson and P Flicek and H Parkinson and A Castro and S Fessele and R Steinkamp and M Hagn and M Raess and \{de Angelis\}, MH and J Bottomley and R Ramirez-Solis and D Smedley and S Ball and A Blake and M Fray and J Kenyon and AM Mallon and S Brown and M Massimi and R Matteoni and G Tocchini-Valentini and Y Herault and G Kollias and B Ulfhake and J Demengeot and C Fremond and F Bosch and L Montoliu and R Soininen and K Schughart and C Brakebusch and R Sedlacek and T Rulicke and C McKerlie and B Malissen and F Iraqi and J Jonkers and H Russig and Danny Huylebroeck",

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doi = "10.1093/nar/gku1193",

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Meehan, TF, Chen, CK, Koscielny, G, Relac, M, Wilkinson, P, Flicek, P, Parkinson, H, Castro, A, Fessele, S, Steinkamp, R, Hagn, M, Raess, M, de Angelis, MH, Bottomley, J, Ramirez-Solis, R, Smedley, D, Ball, S, Blake, A, Fray, M, Kenyon, J, Mallon, AM, Brown, S, Massimi, M, Matteoni, R, Tocchini-Valentini, G, Herault, Y, Kollias, G, Ulfhake, B, Demengeot, J, Fremond, C, Bosch, F, Montoliu, L, Soininen, R, Schughart, K, Brakebusch, C, Sedlacek, R, Rulicke, T, McKerlie, C, Malissen, B, Iraqi, F, Jonkers, J, Russig, H & Huylebroeck, D 2015, 'INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community', Nucleic Acids Research, vol. 43, no. D1, pp. D1171-D1175. https://doi.org/10.1093/nar/gku1193

TY - JOUR

T1 - INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

AU - Meehan, TF

AU - Chen, CK

AU - Koscielny, G

AU - Relac, M

AU - Wilkinson, P

AU - Flicek, P

AU - Parkinson, H

AU - Castro, A

AU - Fessele, S

AU - Steinkamp, R

AU - Hagn, M

AU - Raess, M

AU - de Angelis, MH

AU - Bottomley, J

AU - Ramirez-Solis, R

AU - Smedley, D

AU - Ball, S

AU - Blake, A

AU - Fray, M

AU - Kenyon, J

AU - Mallon, AM

AU - Brown, S

AU - Massimi, M

AU - Matteoni, R

AU - Tocchini-Valentini, G

AU - Herault, Y

AU - Kollias, G

AU - Ulfhake, B

AU - Demengeot, J

AU - Fremond, C

AU - Bosch, F

AU - Montoliu, L

AU - Soininen, R

AU - Schughart, K

AU - Brakebusch, C

AU - Sedlacek, R

AU - Rulicke, T

AU - McKerlie, C

AU - Malissen, B

AU - Iraqi, F

AU - Jonkers, J

AU - Russig, H

AU - Huylebroeck, Danny

PY - 2015

Y1 - 2015

N2 - The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.

AB - The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.

U2 - 10.1093/nar/gku1193

DO - 10.1093/nar/gku1193

M3 - Article

C2 - 25414328

SN - 0305-1048

VL - 43

SP - D1171-D1175

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - D1

ER -