Abstract
The ubiquitin proteasome system plays important role in virus infection. A previous study showed that the proteasome inhibitor MG132 could potentially affect hepatitis E virus (HEV) replication. In this study, we found that MG132 could inhibit HEV and hepatitis C virus (HCV) replication-related luciferase activity in subgenomic models. Furthermore, treatment with MG132 in a HEV infectious model resulted in a dramatic reduction in the intracellular level of HEV RNA. Surprisingly, MG132 concurrently inhibited the expression of a luciferase gene used as a control as well as a wide range of host genes. Consistently, the total cellular RNA and protein content was concurrently reduced by MG132 treatment, suggesting a nonspecific antiviral effect.
Original language | Undefined/Unknown |
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Pages (from-to) | 435-439 |
Number of pages | 5 |
Journal | Archives of Virology |
Volume | 160 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2015 |
Research programs
- EMC MM-04-20-01
- EMC MM-04-20-02-A